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Posts with tag production

Zinc Does Not Prevent Diabetes

Despite claims by zinc supplement manufacturers that the pills can help prevent type 2 diabetes, clinical trials do not support this hypothesis.

Laboratory research suggests that zinc helps promote the production and action of insulin. A four-week study of 56 obese women found that zinc did not have an effect on factors associated with the development of diabetes. This study was an example of one trial that treated 56 people with either zinc or a placebo for four weeks and found no effect. This single trial is too small and too short to tell us anything about the effectiveness of zinc in preventing the development of type 2 diabetes.

Research does support that zinc plays a key role in the regulation of insulin production and glucose utilization. Diabetics have shown a zinc deficiency, which impairs their ability to use glucose. However this fact does not confirm zinc as a supplement to prevent the development of diabetes. I apologize it's a nonevent insofar as news. But look at it this way – it's one trial. Nobody says you have to cross it off your list because 56 obese women didn't see a change in their risk factors for developing diabetes. One study is not gospel.

Slowing down Glucose Production

Anybody ever frustrated with left-field highs? You haven't had a morsel to eat in hours and you're stymied (if not righteously furious) your sugar is off the wall. I've been there. No sir, I don't like it. Where is this high coming from? Thank your liver. Researchers are working on a drug to slow down the body's overproduction of glucose when our bodies lock-down in fasting mode. Halleluiah.

A key enzyzme involved in the metabolic pathway used to produce glucose is phosphoenolpyruvate carboxykinase. This enzyme helps control blood sugar levels during a fasting period. Researchers believe an overproduction of the enzyme might lead to the bamboozling highs we sometimes encounter after a long period of...well...nothing!

A proof of concept study shows that it is possible to alter the activity of phosphoenolpyruvate carboxykinase without directly interfering with homeostatic functions of metabolism. This research could be used to design a drug that can prevent the liver from overproducing glucose in a person with diabetes. I'll thank the Lord when this one hits the shelves.

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