Phosphagenics Limited is developing a skin gel that administers insulin. They are currently testing the effect of long-acting insulin in the patented formula.
Research has demonstrated that a single application of the insulin gel rapidly delivered insulin into the bloodstream without any adverse reactions. Additionally, it significantly lowered blood glucose, insulin and c-peptide levels.
The company has been working on improving drug effectiveness and cost efficiency through a process called phosphorylation. Many enzymes and receptors are switched "on" or "off" by phosphorylation, including the glucose lowering properties of insulin. Once inside the skin -- enzymes activate these properties, impacting the blood sugar. This does not cause irritation to the skin, allows for a sustained release of medication in just one application, begins to take effect within an hour of application, can be used with many forms of prescriptions (small and large molecule medicines), and is economical to produce.
If it significantly reduced c-peptide levels, this might be more appropriate for type 2 diabetics - for a temporary basis. Judging by numbers, majority rules and since 80% of diabetics are type 2...this could be a feather in the capitalists cap for pain-free insulin delivery. However, if blood sugar control becomes as easy as a handi-wipe, how motivated will anyone be to eat right and exercise? Wash your hands for dinner, please.












