Results from a recent study reveal oral contraceptives are not all alike.

Researchers from the Kaiser Permanente Medical Care Program of Northern California recently released evidence linking oral contraceptives containing a highly androgenic progestin to a 43% increased risk of gestational diabetes, when used for five years leading up to pregnancy. Interestingly, oral contraceptives with a low androgenic progestin were associated with a 16% decreased risk of gestational diabetes.

Gestational diabetes develops in about 4% of pregnant women who have never had diabetes, but exhibit high blood sugar levels during pregnancy. Untreated, it can be dangerous for both mother and baby.

The study selected 356 women with gestational diabetes and 368 women without the condition from a multiethnic cohort of 14,235 women who delivered a baby between January 1996 and June 1998. The women were members of Kaiser Permanente for a minimum of five years before pregnancy and screened for the condition between 24-28 weeks of pregnancy. Medical records and pharmacy data were utilized to determine contraceptive use.

Researchers state their results support other related studies that confirm more androgenic oral contraceptives can impact glucose tolerance.

Central obesity is associated with insulin resistance through factors that are not fully understood. Researchers studied the effects of three different diets on body fat distribution, insulin sensitivity and peripheral adiponectin gene expression.

Adiponectin is secreted from fat tissue into the blood. The presence of adiponectin can result in improved insulin sensitivity and glucose tolerance, and can assist in mobilizing sugar out of the blood The hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes, obesity, atherosclerosis and non-alcoholic fatty liver disease.

The study involved 11 volunteers who were the offspring of obese type 2 diabetic patients with noticeable abdominal fat deposits. The volunteers were considered insulin resistant and they maintained average hemoglobin A1c levels of greater than 6.5% without medication. All subjects underwent three dietary periods of 28 days each in a crossover design: a) diet enriched in saturated fat (SAT), b) diet rich in monounsaturated fat (MUFA; Mediterranean diet) and c) diet rich in carbohydrates (CHO). Weight, body composition and resting energy expenditure remained unchanged during the three dietary periods. However, when patients were fed a CHO-enriched diet their fat mass was redistributed towards their abdominal region and their periphery fat accumulation decreased compared with a diet MUFA-rich and high SAT diets. Changes in fat deposition were associated with decreased levels of adiponectin after meals and lower insulin sensitivity.

The results of this study conclude a diet rich in monounsaturated fat prevents central fat redistribution and a decrease in after meal adiponectin levels. These findings support the belief that a carbohydrate-rich diet in insulin-resistant subjects exacerbates the insulin resistance. The moral of the story is: to enhance insulin sensitivity - look for a diet rich in monounsaturated fats and less dense in carbohydrates. Chances are if you've tinkered around with your food pyramid - you already knew the results of this study.

Could it be that social evolution has made vitamin D deficiency a necessary evil? Studies have shown favorable effects on insulin secretion and insulin resistance in type 2 diabetic patients who received vitamin D3 supplementation.

The study evaluated 10 females with type 2 diabetes. The patients enrolled in the study treated their diabetes with oral medications. The study was conducted in March, when levels of vitamin D are lowest due to lack of sunlight. A group of 17 females with normal glucose tolerance served as a control group. The diabetic patients were treated for a month with vitamin D3. After the month, the patient's receiving vitamin D3 had increased their insulin secretion levels significantly by 34.3%. The results showed a decrease of 21.4% in insulin resistance after one month of vitamin D3 supplementation.

Back in the day, our ancestors would have full body exposure to the sun throughout the year. Nowadays, that number has been reduced to a mere 5% with only our face and hands acting as a welcome mat for the sun. A major source of vitamin D is its production in our skin as a result of UV exposure from sunlight. Lest we not take Mother Nature's generosity for granted. Everybody looks good with a little color. It'll look even better when your A1c drops as your sun-kissed glow picks up. If all else fails - you can always run off to a nudist colony where social reservations and clothing are optional!

Knocking out the gene for a peptide associated with insulin was shown to protect mice against the harmful effects of a high-fat diet. Urocortin 3 plays a role in the increased production of insulin in response to high caloric intake in animals.

Scientists found that by removing the urocortin 3 gene from mice, they did not develop the age-related insulin resistance and high blood sugar observed in the normal control mice. The metabolisms of normal mice were compared to the metabolisms of those without the urocortin 3 gene. When placed on a high caloric diet for three months, the mice without the urocortin 3 gene packed on the same amount of weight but had lower insulin levels. But these mice also had lower blood sugar, improved glucose tolerance curves and they did not develop the fatty livers the control mice experienced.

Scientists hypothesize that by curtailing the abnormally high insulin levels, they were able to manipulate insulin sensitivity and avoid some of the untoward consequences of the high food intake and weight gain. Like many of us diabetics already know too well - while insulin is effective at lowering blood sugar it also promotes fat storage. This is a natural protective response to prepare for times when food may not be available. When insulin is produced at too high a level for too long, the body becomes insulin resistant and blood sugar and certain blood lipids gradually creep up, which can cause progressive damage to multiple organs.

Urocortin 2 and urocortin 3 are part of the system that governs the body's response to insulin. Scientists already know that mice on a high-fat diet do better if either urocortin 2 or urocortin 3 is removed. Now they want to know if the mice will respond even better if both are missing. Such results may instruct us how best to develop therapeutic means to exploit these powerful effects.

Yes, that's what it says: curbing the diabetic epidemic with 6 oat waters. CeaProve® is a new test for the early detection of pre-diabetes or impaired glucose tolerance that may help curb the diabetes epidemic. For those of you who have endured a glucose tolerance test - you'll understand the pivotal importance of this new diagnostic test. Ceapro has developed a test that identifies people at risk of type-2 diabetes as early as 5 to 10 years before the disease is diagnosed.

The simple test involves eating 6 oat-wafers and undergoing a finger prick. The test - when repeated at six month intervals - can also show if lifestyle changes are being effective or if more treatment is needed. Ceapro has tested CeaProve in the workplace of several prominent businesses in Edmonton that are interested in helping their employees monitor and preserve their health. Over 90% of tested volunteers were unaware of their risk for diabetes. Of the population studied, 60% were overweight, 56% were over the age of 40, 44 % had a family history of diabetes and over 57% had more than two risk factors for the disease. Although Ceapro is a Canadian-based company, they expect to have Ceaprove available in commercial quantities within the next 45 days. The product will likely be released through regional health initiatives and may also be available through pharmacies and medical laboratories.

Can such a simple test have such a significant impact on the future of one's health? The results tell people, years ahead of time if they are heading down the path to diabetes. With dietary modifications, regular exercise, and an overall improve in lifestyle - wouldn't it be worth it to you?