The scientific community has been in a heated debate about xenotransplants (transplanting pig islets into humans). Although the procedures are showing to be effective - is the insulin secretion entirely pig? Some experts surmise that after the transplants, diabetic patients are actually able to produce some insulin on their own, after all.

The latest press release from Tissera, Inc (an Israeli-based company) made a statement that raises my hopes. It was, "By the fourth month after transplantation, the insulin dose needed to maintain near-normal blood sugar levels decreased by more than 90% in comparison with the insulin dose needed before transplantation, meaning that endogenous insulin production was predominantly responsible for blood sugar control."

The question of the origin of endogenous insulin was addressed by measurement of blood C-peptide. C-peptide splits from insulin and indicates the level of insulin secretion from the patient. C-peptide levels were measured both at baseline and in response to a sugar load, which brings about a rise in blood C-peptide. The measured C-peptide was shown to be predominantly of pig origin. So herein lies my question: is predominantly more than 50%? A type 1 diabetic has undetectable levels of C-peptide. Period. After the xenotransplant the C-peptide level is all of a sudden detectable? Could these islet transplants assist in regenerating the diabetics' own islets?

That's Fit did a great piece featuring the benefits fiber adds to most of our diets. In fact, the FDA recommends we eat 25 to 30 grams a day when most of us are eating less than half that amount!

Even Oprah is praising the nutritious secrets of fiber. Her helping hand, Dr. Oz, has written it all down for you in his latest book, YOU on a Diet. Oprah has featured the YOU: On a Diet Basics in a slide show on her site.

The slide show compels me to brave Borders again (at least this time I might not have to navigate swarms of Harry Potter fanatics). YOU: On a Diet promises to invigorate me with equal parts information, motivation, and change-your-life action that will harmoniously direct my body into wellness. After all - this is the doctor who has helped Oprah look like a daytime supermodel. I'm sold!

The CafePharma message boards are for pharmaceutical sales professionals and those interested in the pharmaceutical industry. A former Lilly sales rep started a thread about Eli Lilly and the lies they've told over the years. Pro Lilly responses flooded in, as did the anti-Lilly responses. Yesterday, however, two comments seemed to hit the message board with a vengeance.

Comments #23 and #24 epitomize the anatomy of a good old fashioned debate. Comment #23 is an Eli Lilly sales rep who claims to have helped with the successful launch of rDNA insulin, and the conversion of patients on pig and cow insulin to Humulin. He remarked from the perspective of a salesman that it was a successful venture resulting in unilateral domination. In response to his yesteryear achievement - commenter #24 raised some wonderful counter-points for modern day consideration. The following paragraph summarizes the results 25 years after the market saturation of Humulin and genetically modified human insulin.

The adverse events include: (1) Complications of diabetes are increasing. (2) Dead-in-bed syndrome is up over 300%. (3) Traffic accidents caused by people using rDNA insulins are increasing (especially in Type 2). (4) rDNA insulins are producing immunogenic responses in the same manner and numbers in the diabetic population as did pig and cow insulins. (5) No long-term studies have ever been conducted to define the dangers of the synthetic insulin hormones relative to cancer and other diseases.

Of course my favorite point is the fact that recent studies have shown that the culprit in many Type 1 diabetics may actually be the human insulin antibody produced by the diabetic. This may be self-serving beyond Type 1 diabetics needing insulin - it's giving Type 2s the very same problem.

Mad Money is a stock show on CNBC hosted by Jim Cramer - a well-known iron fist on Wall Street. He has a following of stock enthusiasts who regard his recommendations (buy or sell) as gospel. Why is he so good at what he does? He just wants to help you make money.

And to this end -- the reason I bring Cramer's passionate drive to The Diabetes Blog is simple: last week he called Novo Nordisk as a SELL. Cramer said he's beginning to worry about a backlash on drug stocks. He advised that viewers should not be greedy and should take gains in Novo Nordisk (NVO).

Perhaps the NY Times article raised some eyebrows at Big Pharma. It appears doctors are receiving handsome gifts and stipends for handing out samples of drugs that were not all that safe for most patients. The payments give physicians an incentive to prescribe the medicines at levels that might increase patients' risks of heart attacks or strokes. In light of this blood curdling synopsis Novo got a dishonorable mention. Novo Nordisk professes to operate their company in two parts: biopharmaceuticals and Diabetes Care. The Diabetes Care segment provides insulin analogues, human insulin and insulin-related products, and oral antidiabetic drugs.

The cross examination of the C-peptide disappearing act and mysterious insulin auto-antibodies appearing where they shouldn't is just getting started. Thanks for making them sweat, Cramer!

No kidding! The rats are leading researchers to triggering events causing diabetes. The new findings suggest that there is, indeed, a genetic susceptibility to diabetes, but that the precipitating event is a viral infection.

The virus in question is the Ljungan virus. Previous reports indicate that infections with the Ljungan virus can induce diabetes in laboratory rats, and that the diabetes can be reversed if the animals are treated with antiviral drugs before the destruction of insulin-secreting islet cells becomes widespread.

I'm not sure how everybody else out there got their D-card. My diagnosing event happened shortly after I had the chicken pox, back in '85. The childhood christening event apparently left me out in the cold and caused the love-hate relationship between my islets and my insulin autoantibodies. Lucky me. Thanks to all the readers out there who have already shared their sequence of diagnosis with me. What's your story? Please, share with us.

It is with great pleasure that I have the opportunity to blog about someone I consider to be a first string player in the sport of diabetes. Her name is Kerri, and her position is all over the place! Yes, you read that correctly. Kerri is a trifecta of talent. She currently works as an editorial assistant for dLife, where she writes a monthly column, "Generation D." She also finds time to contribute as a co-editor for EXIST Magazine, an online resource of CNN news with an MTV voice. You might recognize her co-editor (who is also her ever-supportive boyfriend) Chris Sparling. But the main event that drew my attention to Kerri was her blog, Six Until Me.

She started SUM in May of 2005 after Googling "diabetes" and finding not much more than a list of complications and the American Diabetes Association website. She was one of the pioneering blogs in the diabetes community. When she first set it up, SUM was one of 5. Nowadays you'll find more than 150 diabetes blogs out there in cyberspace. SUM has become reassurance for Kerri that she is not alone in dealing with diabetes. Having that kind of reassurance means the world to her, as I'm sure it does for those of us reading. Kerri puts her heart and soul into SUM and I invite any of you who spend a few minutes there to prove me wrong.

Throughout her twenty-something years of experience as a type 1 diabetic, Kerri insightfully shares her tricks of the trade in diabetes management. Grab a pen because this girl knows what she's talking about! First, she says to test often. Yes ma'am. You can't argue logic and that seems to be the only avenue open these days to tight control. Her second suggestion is just as important, but far more effective: personal forgiveness. Kerri says: diabetes is a very psychological disease... There is no such thing as a perfect diabetic. But you can be one that tries your best. Don't do yourself the disservice of calling certain foods "bad," because you don't deserve that. If your management takes a tumble, dust yourself off, forgive yourself, and move on. Life is too short to be saddled with guilt. Kerri, your words epitomize the emotional exuberance we all need to withstand diabetes. You inspire me. You share your wisdom in ways that make me proud to have you along for the ride on the D-train. That alone, should win you the Diabetes OC Awards, for which you have been nominated. Good Luck and congratulations on your ever-growing success!