In two weeks, Bernard Farrell will be riding in the Bike the Miles annual fundraiser to support Dr. Faustman's research to cure Type 1 diabetes. His participation is especially intrinsic because it is one day away from his 35th anniversary of becoming a Type 1 diabetic.

Bernard plans to raise $10,000 for Dr. Faustman's research. Last year he raised $7,500. The entire event raised a whopping $301,000! All of this funding is going toward the human trials to cure Type 1 diabetes. After discovering that the insulin-producing islet cells of the pancreas are capable of regeneration, Dr. Faustman now needs to test her treatment, already known to be safe in humans, to see if the effects are as positive as they were in the animal model.

It goes without say that this is terribly important for Bernard as much as it is for every man, woman and child touched by Type 1 diabetes. Bike the Miles is an annual event that was started by Susan Root and Jacqueline Fusco in 2004. Both, Susan and Jacqueline, have children who are Type 1 diabetics. Please visit Bernard's site to support his ride and the drive to cure Type 1 diabetes!

Juan Domínguez-Bendala, Ph.D., is Director of Stem Cell Development for Translational Research at the Diabetes Research Institute. Once again, thanks to Gina and Jon at Diabetes Talkfest - you'll have the opportunity to chat live with Dr. Domínguez-Bendala on August 23rd at 9pm Eastern Standard Time.

Dr. Domínguez-Bendala is currently involved in several projects that focus on the use of embryonic stem cells to obtain pancreatic islets, in the hopes that these newly developed cells could one day be transplanted into patients with type I diabetes.

Join Dr. Domínguez-Bendala to discuss his work and ask questions pertaining to embryonic stem cell research. I know I'll be there, in true form, asking questions that I've been archiving for an event like this one!

Hear ye! Hear ye! I have an announcement to make. About 3 months ago, a committee formed to explore the possibility of creating a new conference series for adults with type 1 diabetes. Most conferences are currently geared towards all types of diabetes, but a group of us felt there should be more for the unique challenges that are posed to adults living with type 1.

With that in mind, we are conducting an interest study for the conference. Who would you like to see at the conference? Tell us what is missing from Type 1 diabetes (besides the obvious **cure**). This will help us with programming, as well as securing sponsorships for the event. Besides giving you all you want from the latest and greatest in type 1 diabetes - you have a chance to leave your mark on this revolutionary event. At the end of the survey, there is a question about creating a name for the conference. The committee will choose the winning name. The winner will receive an autographed copy of Know Your Numbers, by Amy Tenderich and Dr. Richard Jackson. The second and third places prizes are a Six Until Me mug and a Diabetes Mine mug, donated by Kerri Morrone and Amy Tenderich.

The survey closes on Friday, September 7, 2007 so don't miss your opportunity to voice your opinion. Take the survey today!!

Read all about it. Professor Vincent Marks, a world expert on insulin who has assisted in some high profile cases of insulin murder, has written a book - the 'Insulin Murders - True Life Crimes'.

The first recorded incident of insulin used for murder was in 1957, and since then there have been about 50 cases globally of insulin being used for murder. Although insulin can be used to kill, Professor Marks said it was actually a very poor murder weapon. Detecting its use was difficult, but not as many assumed...impossible.

It is not a very good weapon especially nowadays. More tests are available to prove the misuse of insulin. If a non-diabetic is dead on arrival without a usual suspect - I suggest the coroner check the patient's blood sugar. If that's hovering around absolute zero I'd put a request in for the insulin antibody kit!

The Master Cleanser Detox raises my curiosity to insatiable levels. Many stars have sworn by it - from Beyonce Knowles to Robin Quivers. The misconception behind the safety of this practice for weight loss is reviewed by a registered dietician on The Diet Channel. The Master Cleanser is by no stretch of the imagination a healthy way to lose weight. In fact, the Master Cleanser, otherwise known as the Lemonade Diet, is a complete body detoxifying cleanse that has been around for over 60 years.

The Master Cleanser is a combination of simple ingredients in different combinations throughout the day: organic sea salt, water, lemons, syrup, cayenne pepper and a laxative tea. The day begins with a quart of salt water, followed by interval consumption of several cups of homemade lemonade throughout the day. The lemonade contains fresh squeezed lemons and water, cayenne pepper, and maple syrup. The lemon juice is said to dissolve built-up waste in the colon (the master cleansing agent); the cayenne pepper is for ridding the body of mucus; and the maple syrup is for energy. The end of the day includes a detoxifier herbal tea laxative. The herbal laxative is to aid the elimination process and the salt water acts as a colonic flush. The author of the original plan recommends following the diet for a minimum of 10 days, but also says that the diet can be followed for up to 20 days.

On Friday I went to Borders to get my hands on a copy of the Mater Cleanser. Big mistake after I realized it was the debut of the latest Harry Potter book. I should've called! In any event - I forfeited fighting Gryffindors and Hogwarts to find the book. I returned home to scour the internet for personal reviews of the Master Cleanser. The most important thing I discovered was that people who use the Master Cleanser to lose weight are misinformed. The Master Cleanser is intended for ultimate toxin elimination - not weight elimination. For entertaining enlightenment - I strongly suggest reading the Amazon.com customer reviews!!

Dr. Faustman's lab is currently collecting blood samples from individuals with established Type 1 diabetes. These samples are being used to quantify the number of autoreactive T-cells and develop the adequate dosage for Phase 1 of human trials to cure Type 1 diabetes.

The research has been presented and the NIH confirmed it. By reeducating the confused T-cells and instructing them not to attack healthy islets, an apparent cure of established type 1 diabetes in non-obese diabetic mice is possible. Now, Dr. Faustman is collecting human samples to bestow the same cure for diabetes in humans.

If you wish to be a part of this revolutionary event for curing Type 1 diabetes, please contact the Clinical Coordinator or call Dr. Faustman's lab at (617) 726-4084. Each participant is asked to bring a control person along with them - an unrelated person without Type 1 diabetes or another autoimmune disease. Diabetic or not - you can be a part of history in curing Type 1 diabetes!

Eli Lilly has an award they give to people who have been diabetic for 25, 50 and 75 years. They call it the Lilly for Life Award. The award recognizes people who have been enslaved to the exorbitant expenses of diabetes management, in addition to the other schedules of daily life. Endearing isn't it? The award is a significant token of Lilly's appreciation for all you have endured and sacrificed.

Lilly awards people who have used insulin for 25 years with the monetary equivalent of what your diabetes management has cost. All your copays for each bottle of insulin, each box of syringes, each blood sugar testing strip, and your ability to adapt to the ever-changing technology of diabetes care (I swear, it says that in block letters) - Lilly awards you $42,500!! I told you I lived in the land of milk and honey. ACTUALLY - it's a medal and a consent form to have your face exploited in Big Pharma marketing. You should've bought the stock! The shareholders of LLY paid approximately $1.75 per share 25 years ago, when you were diagnosed. Today that share is worth approximately $56. Anybody know the math on that return? It's probably around 3,000%.

Let's go back to that statement ever-changing technology of diabetes care. Why must it be ever-changing? Doesn't that sound a lot like never-ending? We need not spend too much time on identifying how to treat this disease when we've got that down. What we need to do is spend more time and energy on preventing the disease from happening in the first place. That is what I consider achievement. Achieve that, Lilly! And by the way - I'll take 3,000% of my $42,500 while you're at it. Thanks.

Meet the Face of Change is a photo exhibit owned by Novo Nordisk featuring YOU -- the face of change. Change for what, I asked? Well, it seems Novo would like to change your opinion of the barriers to insulin treatment for Type 2 diabetics. The common belief of insulin treatment for Type 2 diabetes is that it is the point of no return. Why? First instincts are usually correct.

Studies have shown that Type 2 diabetics injecting insulin create insulin antibodies (IAA). Type 1 diabetics have these antibodies upon diagnosis. Type 1 diabetes was also formerly referred to as insulin-dependent diabetes. Insulin antibodies (IAA) develop and attack the natural insulin produced, resulting in insulin dependence. Type 2 diabetics do not have the same level of IAA. Once they begin injecting insulin that looks like human insulin (the kind Novo makes) - you run the risk of developing IAA. The use of animal-insulins did not cause the development of IAA to the same extent. If you plan to start injecting insulin - ask your doctor if he will check you for IAA. As a Type 2 diabetic, you DO NOT have to become an insulin-dependent diabetic.

I asked Novo to explain what Meet the Face of Change is about. What are they trying to change? The response I received from Nov explains their wishes to strengthen the drive of their business, among other core values. Now I ask you - how do you drive a business that sells insulin? Sell more insulin. For the 16 million Type 2s not yet in this lineup- please consider if insulin-dependent diabetes is the face you want to meet. Don't add insulin to injury. It may not be the path of least resistance, but cut back on simple sugars, increase fiber consumption, and take a walk after dinner. Meet the face of change by putting your best foot forward, not your face on a campaign for vulture capitalism.

Circumstances of confusion invalidated a Diamyd clinical trial to protect insulin-producing cells in diabetes patients. This confusion amounts to a speed bump, but Diamyd intends to press on.

The company admitted that the Phase II clinical trial of its gene therapy had been botched following a mix up over which patients received the drug and which got placebo. Diamyd is a vaccine based on GAD65, a major factor for diabetes due to an autoimmune reaction. The company designed the vaccine to reduce the need of insulin injections and prevent the destruction of beta cells that produce insulin in the pancreas. Also, by protecting these cells, it may allow them to regenerate in a non-autoimmune environment, and possibly set the stage for a cure of the disease.

Anders Essen-Möller, CEO of Diamyd, said: "Was the drug mixed up? We do not know. Could there be a mix-up at some other times in the study? Yes it is possible, but that is not certain." Essen-Möller is determined not to let the mistake ruin the vaccine's progress towards approval. Essen-Möller also said he believes that the invalidation of the trial will not adversely affect any ongoing meetings with potential partners.

The B.A.D Ride was born ten years ago in Southern California. B.A.D as in Bikers Against Diabetes. Rip Rose, a biker and photojournalist for Easyriders, wanted to bring the biker nation together in the fight against diabetes. Today, that dream is a reality.

On Sunday morning, June 10th, nearly two dozen Harley-Davidson motorcycles roared to life, heading out to Oak Canyon Park in Irvine, where they were joined by hundreds of other riders from Southern California at a fair with bands, food, vendors and a ride-in bike show. Sunday's event marked the ride's 10th anniversary. Rip's B.A.D Ride partners with the American Diabetes Association, and 80% of the money raised goes to diabetes research.

This story goes out to my dad, Bizzle. He's a HOG (a member of the Harley-Davidson Owners Group). He's told me they are the nicest people you will ever meet and that is why he enjoys his open road adventures. It looks like he's right. I think he would love to join a Rip's B.A.D Ride. Those of you HOGs interested in upcoming rides for diabetes, checkout the schedule. Thanks to all those who fire up for the sake of diabetes!

For more the more than 300,000 users that once relied on animal-derived insulin, the final chapter of animal insulin is finally ending for the US market. In December 2007, Novo Nordisk has officially decided to discontinue making animal-insulin. Their explanation doesn't go into great detail why they chose to discontinue it. But the supporting evidence they use to warrant the decision is a little weak.

Novo says, animal insulin is derived from the pancreas of slaughtered animals. This statement is as true as the statement "human insulin is derived from the pancreas of slaughtered humans". Novo continues, since that time there has been significant improvement of insulin quality and formulation. Absolutely true! In fact, a Novo pork product was shown to be greater than 99% pure, while an Eli Lilly human insulin only exceeded the 97 percentile. As a consequence, demand for these old animal insulins has declined by as much 20% in the last year to a point where approximately 2% of all insulin users are currently using these products. Largely due to the fact doctor's were advising their patients they must prepare to switch to GM insulin because animal-derived insulin would be nearly impossible to obtain. True. The research that introduced GM insulin (back in the 80s) was preemptive, at best. The claims supporting it was better than the existing insulin choices was clearly debatable .A telling similarity to the discovery about Avandia.

The long-term results of GM insulin and its analogs would prove to be a nightmare if the right questions were asked, and the data properly collected. Is it fair for any of the companies to ask us to change from an insulin product we have grown to love? No, but much like the off-Broadway play suggests: We love you (as a customer). Your diabetes is perfect (for our bottom line). Now change your insulin (we don't feel like making that kind anymore). Too bad type 1 diabetics forced to change to GM insulin didn't have the outspoken advocates like those taking Avandia.

Guess what! If you're vehemently opposed to dieting (doesn't make you a bad person) here's an interesting study: a twice-weekly, 6-month, moderate, aerobic exercise program, without a concomitant weight loss diet, is associated with significant improvements in cardiovascular function in overweight, non-smoking, type 2 diabetic individuals.

The purpose of the study was to determine long-term cardiovascular changes when patients introduced moderate aerobic exercise. The study evaluated the effects on the vagal nerve applied to the heart rate in three different states: at rest, while lying, and while standing. Activation of the vagal nerve typically leads to a reduction in heart rate, blood pressure, or both. The study took place throughout a 6 month program where patients were evaluated twice a week. In a 10-min electrocardiogram recordings (EKG), Heart rate variability was measured by autoregressive power spectral analysis (PSA). This method allows a reliable quantification of the low frequency (LF) and high frequency (HF) components of the heart rate. The heart rate value before and after physical exercise were similar. In contrast, on standing, the heart rate was significantly higher whereas the LF component was significantly lower after exercise. Upon standing, the LF/HF ratio, reflecting the sympathetic vs. parasympathetic balance, was markedly lower. No significant exercise-related changes in these PSA components were observed on lying.

This study shows that the effects of short cardio events (for instance: 10 minutes on the treadmill) will enhance the ability of your heart to support sympathetic nervous system activities for homeostatic mechanisms in living. Furthermore, those same 10 minutes on the treadmill will enhance your parasympathetic nervous system - the internal organization also known as the rest and digest system. The parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract. Sympathetic and parasympathetic divisions typically function in opposition to each other. But this opposition is better termed complementary in nature rather than antagonistic. For an analogy, one may think of the sympathetic division as the accelerator and the parasympathetic division as the brake. The sympathetic division typically functions in actions requiring quick responses. The parasympathetic division functions with actions that do not require immediate reaction.

Fair and balanced, just like Fox News -- I want to let everyone know that the "Matt P" I spoke to, at the ADA responded to my blog about the aforementioned conversation. His response is #17 and it is sincere and genuine -- certifiable in my book. Again, let me reiterate that the nature of my call to the ADA was to ask for their assistance in getting a big pharmaceutical company to sponsor C-peptide FDA trials here in the US. Thanks again to Matt. He really is doing all he can, but there seems to be a suspicious roadblock holding up the research here in the US. Any guesses? Without further adieu, here's Matt:

I hope people will take time to read my reply to yesterday's post about ADA and c-peptide. I work for ADA, and I was the "Matt P" who talked to Allie a week or two ago.

I certainly wouldn't\'t discourage you from calling our 800-DIABETES number, but I think you should consider why we have an 800 number and what the staff of our Call Center are trained to do. Their primary goal is to help people with basic questions about taking care of diabetes. They have very little information about what research is going on in diabetes, because that information does not yet have any relevance for the vast majority of people who need the help of our Call Center. Callers are primarily concerned about nutrition, help with paying for medications, and information about complications. The staff does try to take care of callers who want to give guidance to ADA on things like research and legislative priorities, but their primary focus is on providing immediate, direct advice about diabetes management to people who can't get it any other way.

Again, please read my other reply. Guys, diabetes is awful, everyone who works at ADA thinks so and of course so do all of you. We would all sincerely like to see effective treatments come into our hands immediately, but I'm afraid that there is almost nothing ADA can do to change the basic nature of the research process or the drug approval process. Despite recent promising research results regarding c-peptide, there's no way the FDA would approve it as a therapy for diabetes complications until more research is done to precisely define what it does and how well and how safely it does it.

Could industry do more? Probably, although we don't know exactly what they\'re doing now---please see my other post. We live in free society where people and companies don't always have to tell you what they're doing. If you want my pledge to talk to people at Lilly and Novo about the potential promise of c-peptide, you have it.

By all means, call them yourself. I'm afraid our Call Center staff, who do an incredible job with handling a huge number of calls from a lot of desperate people, aren't going to be able to do much to address an issue that is still at the research stage.

Sincerely,

Matt

The JDRF Government Relations would like to encourage all diabetics to take action and let your Senators know that you want them to support the Senate Bill 5 (S.5) - the Stem Cell Research Enhancement Act. Of course, if you do not support this bill you are in no way expected to do any of the following - but for the sake of enlightenment, I invite you to read on.

This bill is similar to H.R. 3, which passed the U.S. House in January and H.R. 810, which passed both the House and the Senate last year. This legislation will allow federally funded researchers to use additional stem cell lines for their research.

If you wish to take action, and let your Senators know that you support this important bill--you can personalize a letter that will be faxed to your Senators offices on your behalf by following one simple step:

Visit the Take Action page. Review the letter supplied and enter your personal story in the paragraph provided.

So here's my personal story - and why I'm disappointed that any politician appointed for the welfare of the citizens that elected him or her would disrupt the promise stem cell research could offer diseases like diabetes:

My name is Allison Beatty and I am a juvenile diabetic. I was diagnosed in July, 1985. As a type 1 diabetic for over 21 years (and of legal voting age for 11 years) I am disappointed that officials governing the use of my tax dollars have impeded the most promising avenue of research to remedy a National problem like diabetes.

The incentive of those who oppose stem cell research is strictly religious and I am insulted that my quality of life on Earth today is compromised by the FAITH in where they will end UP in the afterlife.

Please do not allow the religious forum to dictate the scientific relevance of one of he most promising answers to address life-threatening illness. I trust your decision as a politician will best serve the needs of those living on Earth today, and not on your destination in the afterlife.

Although they are not currently targeting my Senator(s) for this campaign – that's my personal story, and I'm sticking to it. I hope the politicians who oppose stem cell research can see past their personal crusade to save their soul and start acting on saving lives!

In 1996 a 41 year old male (a type 1 diabetic for 18 years) was injected with biocapsules containing pig islets to regulate his blood sugar level. The transplanted cells helped reduce the patient's insulin requirement by 34% for over a year, which provided better control. By 2005 the patient's glycated hemoglobin levels (HbA1c) remained lower than the pre-transplant levels.

Ten years later, the patent contacted Living Cell Technologies to inform them that he believed the transplanted pig islets were still alive and well. After tests were conducted, it was concluded that the pig cells were (as he reported) still functioning. This proved that the LCT patented technology for xenotransplantation was effective. It allows the islets to survive at least ten years in a micro-capsule coating and continue to release insulin into the patient's bloodstream without immune suppression. After tests we conducted on the type of insulin present in the patients blood - it was with 100% certainty that it was pig and not human insulin.

LCT has significantly advanced the encapsulation process since the 1996 clinical trial and there is an even greater understanding and control over the longevity and robustness of the encapsulation process, as well as the porcine islet cells. LCT will be trialing the DiabeCell pig islet cell transplant in patients in a phase I/IIa clinical trial, expected to begin in Quarter 2, 2007. In addition, LCT is awaiting approval to conduct an additional trial in New Zealand this year with a different treatment protocol. Subsequent trials in the US or Europe are intended following initial results from these studies.

If overseas trials are coming through with flying colors - why aren't we doing this yet? C'mon USA - where's your competitive spirit? All these pigs up in Spring Point might be put to good use, after all. Oink Oink.