There is still no evidence to declare superiority of rapid-acting insulin analogues in the treatment of type 1 diabetes. These studies compared either insulin aspart (NovoLog) or insulin lispro (Humalog) with human insulin; no such study was available for glulisine (Apidra).

Based on average HbA1c values, patients treated with NovoLog had lower levels. However, statistical comparisons were so small that an effect on patients' health is not to be expected. It was also hypothesized that Humalog may prevent night time lows better than Apidra.

Even though patients have been treated with insulin analogues for 10 years, it is still unclear as to how these types of insulin affect long-term complications of type 1 diabetes. The long-term effects of insulin decisively increase the risk of heart disease and cancer, according to recent studies at Howard Hughs Medical Institute. Would you be surprised to learn that one of the insulin analogue manufacturers chose to withhold some of the results of their studies?

It's logical that the Nation is up-in-arms about putting genetically modified meats and produce on the shelves in grocery stores and getting due diligence from the government for it. It makes a lot of sense to test something you will use to fuel your body before it is permitted to penetrate the market. So how did genetically modified human insulin overtake the market again? Oh - there must not be any side effects like a diabetes epidemic or something crazy like that, right?

But I digress on the topic in honor of springtime, when "love is in the air". As we all know, love is one of the strongest forces of nature. So is it fair that it went unnoticed by the FDA that human synthetic insulin results in a loss of awareness of hypoglycemia, among other natural responses to hormonal precursors? This is due to a significant suppression of tachycardia.

Tachycardia refers to a rapid beating of the heart. This event may be a perfectly normal response to stress. A stressful event may cause the endocrine system to release hormones that regulate body functions related to mood, growth and development, tissue function, and metabolism, all of which are governed by blood sugar. The hormone that is critically important in tachycardia is epinephrine (adrenaline).

Epinephrine is a fight or flight hormone which is released from the adrenal glands when danger threatens (hypoglycemia, mating rituals, survival of the fittest). When secreted into the bloodstream, it rapidly prepares the body for action in emergency situations. The hormone boosts the supply of oxygen and energy-giving glucose to the brain and muscles; some bodily processes not vital to the response are suppressed. This is exactly what happens when animals become twitterpated in the spring (Bambi, Walt Disney - 1942).

As the birds and the bees go about their business, pollinating and procreating - I ask you think about the adulterated pharmacological intervention that has impaired such a natural phenomenon as love. Celebrate the body's natural response to tachycardia, and realize that our Creator made us perfectly. The longer you spend in the lab genetically modifying His work - the more you are fighting the forces of nature. Now please, put it back the way you found it.

A study published in 1991, comparing the efficacy of human synthetic insulin to porcine insulin states "there is no reason to treat all insulin-requiring diabetic subjects with human insulin except those who have developed insulin allergy".

In light of this study - how was rDNA synthetic human insulin able to monopolize the US market?

The absence of highly purified porcine insulin in the US is probably (my guess) because it's cheaper to manufacture. The saturation of the US market with rDNA synthetic human insulin seems to be treating the masses with a specialized need existing in only a few individuals. But the top line of this marketing campaign must have had a good effect on the bottom-line, too. Sales reps convinced doctors to switch their patients because it was going to become nearly impossible to continue getting animal derived insulin. The insurance companies (the guys picking up the tab) must've loved this option, too. Why wouldn't they? It's better - right?

I'm going to do a self-analysis of the stuff, based on my IAA, IA and C-peptide levels. I've been on human synthetic insulin since 1985. I've never been on highly purified porcine insulin. The IAA is my insulin autoantibodies -- the antibody attacking my islets. My IA is the insulin antibody attacking the injected insulin and my c-peptide will tell me how much insulin my body is making. After 12 weeks on the highly purified porcine insulin - I'm going to do my labs again. I'm curious to see if these levels move, at all. If my c-peptide levels rise, that's a GOOD indicator what's best for Allie Beatty.

So is the best choice for me the best choice for all? Probably not. But at least I can see for myself - even if it costs me a pretty penny to get my hands on highly purified porcine insulin. Nobody said being an experimentalist was cheap. However, never exploring my options would deeply discount the value of experience.

Now that the US market is suspiciously saturated with human insulin - and many of us diagnosed within the last 10 years did not have a shot at trying porcine insulin - I'd like to set the record straight. When the pharmaceutical companies cherry pick the studies they wish to use for their gain, and not so much for your enhanced quality of life - they must've lost this study.

Please read the entire study (if you have access to it in a local library) but what grabbed my undivided attention was the sentence that says: it was observed that the action of porcine insulin was associated with... a striking increase of prolactinaemia, in relation to semisynthetic human insulin.

Okay -- so as I look deeper into the function of prolactin -- aside from some definite dopamine enhancing activities (if you know what I mean) :::wink wink::: -- it is responsible for the formation of myelin coatings on axons in the central nervous system. This is a certifiable problem that results in diabetic neuropathy and the related side effects (numbness, nerve dysfunction, i.e, ED).

Ex-queeze me? Does this say that human synthetic insulin may be a cock blocking drug?

Sorry for the blunt delivery -- but this is the truth. Why doesn't human synthetic insulin have this listed as a side effect? My guess is: if you had a choice of human synthetic insulin versus highly purified porcine insulin -- and you knew the side effects of human synthetic might take a toll on the health of your sex life -- you might be praying to the porcine gods.

Shame on the companies who knew about this study and kept it undercover so you couldn't...