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Posts with tag HighGlucose

A Specific Fat Type Can Protect Against Weight Gain and Diabetes

Researchers found that the type of body fat an individual has -- - white and brown-- may explain why one person gains weight easier than another.

White fat is the more familiar form of fat that accumulates in the abdomen, thighs, and buttocks. Brown fat burns energy and generates heat. White fat is deposited around internal organs and as visceral fat - the most harmful form of abdominal fat. Brown fat contains small lipid droplets tucked behind tiny energy factories called mitochondria. These cells are most prevalent in cute, little chubby babies, but tend to mostly disappear by adulthood. A 2005 Joslin study discovered genes that control the creation of the precursor cells that give rise to brown fat cells. This latest study shows that brown fat may not disappear in all adult animals and that little collections of brown fat may account for why some mice are protected from obesity and diabetes and others are not.

This study compared the difference in fat metabolism between the B6 mouse and the 129 mouse. The B6 mouse is one of the most commonly used strains in metabolic research and an established model for diet-induced obesity. When placed on a high-fat diet, the B6 mouse develops severe obesity, high blood glucose and insulin resistance with extremely high insulin levels. By contrast, the 129 mouse gains 30% to 50% less weight than the B6 mouse and is resistant to dietary induced obesity and glucose intolerance.

The only difference between the B6 and 129 mice is the type of body fat. The B6 mice had a majority of white fat cells, whereas the 129 mice had over 100 times the number of brown fat cells than the B6 mice. The mice with more white fat cells had a tendency to gain weight and develop diabetes on a high-fat diet. The study showed that the 129 mice had higher basal energy expenditure than the B6 mouse, resulting in a mitigated response to dietary effects. So I guess this begs the question -- how does one turn white fat into brown fat?

Chromium Improves Glycemic Control

Chromium picolinate is one of the most widely debated supplements in diabetes health. A study has shown that it improves glycemic control in patients with type 2 diabetes not adequately controlled while taking sulfonylurea, a drug that increases insulin release from the beta cells in the pancreas.

A 40-week study was designed to examine the effect of adding daily chromium picolinate supplementation to an antidiabetic medication, sulfonylurea. A commonly prescribed treatment for type 2 diabetes was given to 29 subjects for 24 weeks, in conjunction with either chromium picolinate or a placebo. Blood sugar levels of study participants taking chromium picolinate dropped significantly compared to the placebo group. In addition, insulin sensitivity for participants taking the chromium picolinate was increased when compared to those in the placebo group. Study participants taking chromium picolinate also experienced significantly lower abdominal body fat accumulation than the placebo group, and experienced less overall weight gain.

This study demonstrates that chromium picolinate supplementation for type 2 diabetes who are taking sulfonylurea agents significantly improves insulin sensitivity and glucose control. In addition, chromium picolinate was shown to reduce weight gain and fat accumulation compared with the placebo group. The results of this study were first published in August 2006 - but knowing about chromium picolinate today leaves you with ample time to adjust for greater insulin sensitivity and less fattening days to come!

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