Anybody ever frustrated with left-field highs? You haven't had a morsel to eat in hours and you're stymied (if not righteously furious) your sugar is off the wall. I've been there. No sir, I don't like it. Where is this high coming from? Thank your liver. Researchers are working on a drug to slow down the body's overproduction of glucose when our bodies lock-down in fasting mode. Halleluiah.
A key enzyzme involved in the metabolic pathway used to produce glucose is phosphoenolpyruvate carboxykinase. This enzyme helps control blood sugar levels during a fasting period. Researchers believe an overproduction of the enzyme might lead to the bamboozling highs we sometimes encounter after a long period of...well...nothing!
A proof of concept study shows that it is possible to alter the activity of phosphoenolpyruvate carboxykinase without directly interfering with homeostatic functions of metabolism. This research could be used to design a drug that can prevent the liver from overproducing glucose in a person with diabetes. I'll thank the Lord when this one hits the shelves.
