A recent study found an anti-obesity effect in a variety of squashes and pumpkins.

Over an eight-week trial, mice were fed a high-fat diet and supplemented with PG105, a water soluble derivative of the Cucurbita moschata. Their body weight and fat storage was successfully suppressed with PG105. The overall amount of food intake was not affected. Furthermore, PG105 protected the development of fatty liver and increased the hepatic beta-oxidation activity. Results from blood analysis showed that the levels of triglyceride and cholesterol were significantly lowered by PG105 administration, and also that the level of leptin (excreted by fat cells) was reduced. Adiponectin, the modulator of a number of metabolic processes, including glucose regulation and fatty acid catabolism, was increased.

This remarkable effect on fat metabolism was made possible by the decreased abilities of lipogenic genes (fat-producing) while simultaneously kicking up the lipolytic genes (fat-burning). Since this affected the beta-oxidation of fatty acids, it would presumably create a rise in ketones. If the body can maintain normal blood glucose while producing all these ketones, this might demand consideration that ketosis is not only safe for diabetics, but healthy. I'm anxious to see further research.

Researchers found that the type of body fat an individual has -- - white and brown-- may explain why one person gains weight easier than another.

White fat is the more familiar form of fat that accumulates in the abdomen, thighs, and buttocks. Brown fat burns energy and generates heat. White fat is deposited around internal organs and as visceral fat - the most harmful form of abdominal fat. Brown fat contains small lipid droplets tucked behind tiny energy factories called mitochondria. These cells are most prevalent in cute, little chubby babies, but tend to mostly disappear by adulthood. A 2005 Joslin study discovered genes that control the creation of the precursor cells that give rise to brown fat cells. This latest study shows that brown fat may not disappear in all adult animals and that little collections of brown fat may account for why some mice are protected from obesity and diabetes and others are not.

This study compared the difference in fat metabolism between the B6 mouse and the 129 mouse. The B6 mouse is one of the most commonly used strains in metabolic research and an established model for diet-induced obesity. When placed on a high-fat diet, the B6 mouse develops severe obesity, high blood glucose and insulin resistance with extremely high insulin levels. By contrast, the 129 mouse gains 30% to 50% less weight than the B6 mouse and is resistant to dietary induced obesity and glucose intolerance.

The only difference between the B6 and 129 mice is the type of body fat. The B6 mice had a majority of white fat cells, whereas the 129 mice had over 100 times the number of brown fat cells than the B6 mice. The mice with more white fat cells had a tendency to gain weight and develop diabetes on a high-fat diet. The study showed that the 129 mice had higher basal energy expenditure than the B6 mouse, resulting in a mitigated response to dietary effects. So I guess this begs the question -- how does one turn white fat into brown fat?

A diet rich in black soya beans (UK) or soybeans (US) could help control weight and even prevent diabetes. The laboratory research on rats found the beans could also lower cholesterol levels.

Four groups of 32 male rats consumed a fatty diet for 28 days. Each group was given different amounts of black soya beans, with one group receiving none and acting as a control. The rats eating 10% of their energy from black soya beans gained about half as much weight as those in the control group. Total blood cholesterol also fell by 25% and LDL levels ("bad" cholesterol) fell by 60%. Soya protein may have an effect on fat metabolism in the liver and adipose tissue, reducing synthesis of new fatty acids and cholesterol. It is this metabolic effect that may explain the traditional Asian use of black soya in the treatment of diabetes. 'The key problem in type 2 diabetes is impairment of insulin action due to excess abdominal fat tissue. Any loss of weight often improves glycaemic control.

The research is preliminary but the popularity of soya foods has been increasing over the past few years. You've got to cook something for dinner tonight. Why not give black soya beans a try? Cooks.com offers a few recipes to put your soya beans to good use. Anybody up for soya bean burgers or baked soya beans? The Diabetic soya bean cookies caught my attention. Watch-out, Betty Crocker!!

Remember the A-Game suggestions I dangled for Eli Lilly to tap for performance enhancement? Well here it comes. I called Eli Lilly headquarters to speak with the Chairman and CEO, Mr. Sidney Taurel but I was directed to their idea submission form (which consequently didn't work). Oh boy, Sid. I'm a little disappointed. So here goes - my idea is going free for all when you could've had it, first. Let's call this new and improved product Beta Juice. It delivers the essential functions of a fully operational beta cell. It produces: insulin, amylin and c-peptide. Here's why insulin should always come equipped with the other two...

Insulin brings sugar to the cells to keep our energy levels sufficient for life, homeostasis and (if we're lucky) some energy for the gym. Amylin is a controlling agent for appetite, gastric emptying and tells the liver to dispatch glucose. It is also shown to have an impact on lipolysis --- the metabolism of stored fat. Until recently C-peptide was nothing more than a number used to decipher if you were a type 1 or a type 2 diabetic. However, recent scientific studies have shown C-peptide protects small vessels from the complications associated with diabetes. The Reuters Health article is titled C-Peptide Replacement Improves Early Diabetic Neuropathy.

The American Diabetes Association promotes the ABC's of Diabetes Care in an effort to educate diabetics on controlling their disease. The ABC's of diabetes care refer to a patient's Hemoglobin A1c, blood pressure, and cholesterol. A diabetic must maintain a hemoglobin A1c less than 7%, their blood pressure must remain below 130/80 and their good and bad cholesterol must be kept in range. The ABCs of Diabetes Care were established in order to reduces the chances of developing diabetic complications like neuropathy (nerve damage), nephropathy (kidney damage) and retinopathy (eye damage).

Here comes the perfect Insulin (code name Beta Juice) -a laboratory engineered balance of insulin, amylin, and C-peptide. Insulin to balance the blood sugar level, amylin to regulate fat and cholesterol levels and C-peptide to control the damage inflicted upon the micro vessels throughout the body. This is a GREAT IDEA!! Not just because it is MY idea, but because this is a huge opportunity to mitigate the complications that insulin by itself can impose, without the checks and balances of the other beta cell hormones. What do you say, Eli Lilly? You're halfway there!! You've already partnered with Amylin Pharmaceuticals. They have one third of this patent pie. Now hop on the horn and join forces with the C-peptide patent holder and ride your stock price to the moon. The diabetic girl has spoken. I know you care, Eli Lilly. Now put your money where your mouth is and make this new and improved insulin a light at the end of the diabetes tunnel.

An enzyme named eIF2alpha kinase (GCN2) was shown to profoundly regulate fat metabolism in mice.

Scientists provoked the mice into starvation mode by removing a single amino acid named leucine from their diets. By doing this, the body represses fat synthesis and consumes virtually all of its stored fat. After 17 days of a leucine-deficient diet, the mice with GCN2 lost 48% of their liver mass and 97% of the fat from their abdomens. In contrast, the mice without GCN2 kept a steady liver mass and lost only 69% of abdominal body fat.

The mice without GCN2 did not lose as much fat as the mice with GCN2. Furthermore, they developed symptoms that could lead to fatty liver disease. In most events of rapid weight loss, the liver tends to take a beating. However, the fastidious weight loss in the mice with GCN2 occurred because of the repressed synthesis of new fats coupled with the depletion of stored fats. This says a lot for safe handling when it comes to teamwork.

Researchers found a protein that coats the liver is directly correlated with visceral-fat induced diabetes, or type 2 diabetes.

When visceral fat accumulates, the amount of a hormone called adiponectin, decreases. Adiponectin is found in fat cells, and plays a role in glucose regulation and fatty acid metabolism. Researchers found two types of protein on the surface of mouse liver cells. When the proteins and adiponectin interact, blood sugar and neutral fat levels fall, boosting fat-burning functions. However, obese mice with accumulated visceral fat have fewer of these proteins on the surface of their liver cells. When these proteins increased in number, blood sugar levels would decline. The study hypothesizes that if the quantity of adiponectin decreases in obese people, a potential cure for type 2 diabetes may be found by increasing the proteins found on the surface of the liver.

Talk about the power of protein! We've all heard about the leaders in the pack when it comes to dropping pounds - eggs, fish, chicken, soy and whey protein. But this discovery reveals a new way to combat the bulge and reduce your chances of developing type 2 diabetes. Although these new proteins won't find accommodations in your local grocery store - perhaps Big Pharma will have a designer label to sport in the near future. You'd buy it, wouldn't you?

Based on studies conducted at Georgetown University Medical Center, the best-selling wellness author recommends niacin-bound chromium supplementation to improve blood sugar levels, regulate proper insulin function and maintain healthy body weight.

Type 2 diabetics are commonly believed to suffer from a chromium deficiency. Chromium is very important in promoting normal insulin function and is essential for proper protein, fat and carbohydrate metabolism. Elevated levels of insulin and blood sugar significantly accelerate cellular aging. Research now shows that the type of chromium known as NBC (niacin-bound chromium) has a superior anti-aging profile.

Studies conducted at Georgetown University Medical reveal that Chromium polynicotinate (a generic term for ChromeMate) promote: proper insulin function, normal blood sugar levels, healthy blood cholesterol levels, normal blood pressure, cardiovascular health and healthy body weight and lean body mass. Chromium looks like a strong defense for diabetics in the battle against aging and blood sugar control.