Browsing diabetes-related books on Amazon recently, I came across this one: When You're a Parent with Diabetes: a real life guide to staying healthy while raising a family by Kathryn Gregorio Palmer. It caught my eye because 1.) it got very favorable reader reviews and 2.) it addresses a topic that is usually neglected - being a good parent when it's you with diabetes. When You're a Parent was published in September 2006 by Healthy Living Books.

Interesting, that. I mean, there are tons of resources out there about raising children with diabetes and keeping them healthy. This book addresses the needs of parents with diabetes who want to raise healthy happy children, but also have special health needs of their own to remember.

Top 100 Amazon reviewer Manny Hernandez has posted a review to the site and also this site, praising the book. Manny's a good authority, by the way: he has type 1 diabetes and has his own sites including, TuDiabetes and a blog AskManny. Busy!! According to Hernandez, Palmer is informative but never condescending, guiding parents through anecdotes on her own and others' experiences. Palmer covers the gamut from pregnancy to raising teens, adoption, and dealing with depression, diabetes complications, and communicating with your kids about your condition. Sounds like a good resource.

It's common knowledge that diabetes and heart disease are linked. If you have diabetes, you are much more prone to heart disease than are your non-diabetic counterparts. I've sometimes wondered: why should that be? And here comes the answer, courtesy of a recent Netscape health article.

Scientists at Washington University School of Medicine in St. Louis have been examining the issue. Their conclusion? It all comes down to how the body metabolizes fat. The heart cells of diabetics lose a lipid (cardiolipin) designed to provide the heart with energy to function properly. Says Dr. Richard Gross, "Diabetic hearts run mostly on fats for fuel because glucose isn't readily available to them." Problem is, the absence of cardiolipin screws up the heart's cell membranes, both in terms of structure and function.

It's all downhill after the cardiolipin disappears. For one thing, the heart muscle cells begin to be starved of energy. Second, harmful substances form in the cells. Both these factors contribute to heart problems down the road. Observes Dr. Gross, "The pieces of the puzzle of diabetic heart disease are now rapidly falling into place. We hope that these kinds of studies will enable physicians to diagnose diabetic cardiovascular disease sooner and treat it earlier."

Did anybody catch the first ever YouTube democratic debate last week? It was cosponsored by CNN and the cool thing about it was this: all the questions came in from Americans like you and me. Turns out two of the candidates spoke out on behalf of diabetes. Here's what they had to say...

Governor Richardson mentioned the fact that 33% of Medicare is wrapped up in diabetes costs. He suggests, "Let's have major prevention programs, and also ways that we can ensure that we find a cure." He still has not announced a plan to ensure a cure. But if he does - I'm willing to bet all of his campaign funding from Big Pharma might mysteriously disappear.

The other candidate addressing diabetes was Senator Chris Dodd of Connecticut. Dodd's promise came after from a woman's question about stem cell research. Somehow the senator was able to plug an endeavor to "deal with diabetes". However, much like Governor Richardson - he has yet to announce a plan to cure. Politics as usual. Stay tuned for the LIVE Republican Debate on September 17th.

Howard Hughs Medical Experts have discovered the key to a longer life is lower insulin levels. Less insulin helps cells fend off diseases that lead to early death like heart disease, cancer and diabetes. So how does one lower their insulin levels? Caloric restriction by way of eating less carbohydrates.

Caloric restriction postpones the onset of life-threatening conditions like cancer, diabetes, and heart disease. It may still happen, but at a later age. Scientists manipulated genes in mice to produce 50% less insulin and saw the mice live 18% longer. While lowering insulin throughout the body can lead to a diabetic state, scientists found that allowing insulin levels to be high throughout most of the body, and lowering the insulin signaling only in the brain through genetic manipulation, extended the life of mice.

Although the mice were overweight, they lived longer and seemed active and youthful. Scientists believe that this research explains why some people who live past 100 may have a natural genetic tendency for lower insulin signaling in the brain. They eat a normal amount of calories and may even be a bit overweight, but still enjoy the benefit of life extension. This begs the question: if all diabetes oral meds multiply the effect of insulin -- doesn't this increase the chances of heart disease and cancer? New Rule: Black box warning on ALL prescription diabetes drugs!!

Last month Bev addressed a news article that found high tech diabetes management did not equate to better diabetes care. Doctors felt that electronic care is only as good as the patient willing to participate beyond office visits. However, another service is trying to evolve the preconceived notions with a more developed system - and a bigger bang for the buck. How does $14.5 billion sound?

Information technology enabled diabetes management (ITDM) was found to be beneficial in avoiding diabetic complications - MILLIONS of cases. This is an overzealous finding - considering the word prevent is permanent and should probably be replaced with delayed. Even the DCCT knew that much. However, the study was conducted over a period exclusive to the program, and not the lifespan of diabetics in the study. However patient compliance did grow from less than 50% to approximately 80%. That would evoke a few halleluiahs from doctors. Another reason in support of ITDM is the fact that an electronic diabetes registry offers Medicare and other payers the ability to save quite a bit. Over 10 years, the overall net savings is estimated to be $14.5 billion. Does that figure include COLA - cost of long-term diabetes complications adjustment? The complications that did not occur in 2008 saved Medicare and payers $1.45 billion. Score! What is the inflation adjusted cost of those delayed complications occurring in 2013?

The headcount standing at 20 million diabetics, at a savings of $1.45 billion per year - I asked for clarification on that figure. The savings is speculative because the company is anticipating saving costs on preventing diabetic complications. That's optimistic but not entirely realistic.

Story time!! Today is Bastille Day. The French National holiday commemorates the storming of the Bastille, which was a mark of the French Revolution - a revolt against absolute power.

Although I am not French - I am convinced there needs to be a revolution against absolute power of the insulin cartel. You all know them very well - Lilly, Novo and Sanofi Aventis. You've been a loyal customer, in spite of the shortcomings of their products. One example of a shortcoming is the absence of C-peptide. It is found in proinsulin and protects cells from the complications resulting from long-term diabetes. The other is the possibility that another source of insulin might be better for your treatment than synthetic human insulin. The fact the US only offers genetically modified human insulin is not fair when it comes to balance of power. Does this sound like a revolution that a feisty diabetic like me is starting?

I am not here to tickle a revolution. I'm determined to achieve it. Every diabetic deserves the right to choose their insulin. This choice should not be made for you by those who profit from the sale. I'm a type 1. I am a diabetic because my body made antibodies for human insulin. Why must I use insulin that continues creating these antibodies? I'd like to use something a little different that makes antibodies for horse or cow or PIG insulin. Can I get some pork up in here, please? It's difficult to obtain. It's as difficult as Ricky Bobby trying to say something in French. This Bastille Day Blog is a proclamation. As a prisoner of the insulin cartel - I declare that there will be a choice one day soon. Given the choice - you might opt for an insulin revolution, too. Laissez-faire!

Change appears to be coming for diabetes care. The HbA1c test may not be the safest approach for diabetics to follow in preventing complications. Instead, experts are saying the average blood glucose level per individual will add clarity to diabetic patients looking to manage their disease.

A study supporting the change showed a close correlation between average glucose and HbA1c levels. So the myth, busted is: maintaining an average blood sugar is a safer approach for diabetes management -- NOT CHASING A UNIFORM HbA1c value. The fluctuation in blood sugar is what causes complications in the small vessels of the eyes, kidneys and peripheral nerve endings. For example - sustaining a blood sugar of 200 mg/dL is a lot safer than waking at 240 and ushering a boatload of sugar into your cells to drop your sugar to 80 mg/dL. It is the transfer of glucose into the cell that causes the injury to cell membranes and resulting complications.

Think of it like the movement of the ocean. High tide to low tide happens gradually, over the course of many hours throughout the day. When a storm hits - the waves become turbulent, crashing against the shore causing erosion. Is the human body any different? I'm not a doctor -- but I did stay at a Holiday Inn Express last week.

Now that the US market is suspiciously saturated with human insulin - and many of us diagnosed within the last 10 years did not have a shot at trying porcine insulin - I'd like to set the record straight. When the pharmaceutical companies cherry pick the studies they wish to use for their gain, and not so much for your enhanced quality of life - they must've lost this study.

Please read the entire study (if you have access to it in a local library) but what grabbed my undivided attention was the sentence that says: it was observed that the action of porcine insulin was associated with... a striking increase of prolactinaemia, in relation to semisynthetic human insulin.

Okay -- so as I look deeper into the function of prolactin -- aside from some definite dopamine enhancing activities (if you know what I mean) :::wink wink::: -- it is responsible for the formation of myelin coatings on axons in the central nervous system. This is a certifiable problem that results in diabetic neuropathy and the related side effects (numbness, nerve dysfunction, i.e, ED).

Ex-queeze me? Does this say that human synthetic insulin may be a cock blocking drug?

Sorry for the blunt delivery -- but this is the truth. Why doesn't human synthetic insulin have this listed as a side effect? My guess is: if you had a choice of human synthetic insulin versus highly purified porcine insulin -- and you knew the side effects of human synthetic might take a toll on the health of your sex life -- you might be praying to the porcine gods.

Shame on the companies who knew about this study and kept it undercover so you couldn't...

A white elephant is a supposedly valuable possession whose upkeep exceeds its usefulness, and it is therefore a liability. Every type 2 diabetic is a valuable possession to someone: a mother, a father, a sister, a brother, a daughter, a son...you get the picture. But when it comes to the complications of the disease - it costs the U.S. health system an extra $22.9 billion a year to treat these complications.

"It is a pretty significant wake-up call for people, or should be. It really points out the importance of managing the disease," said Willard Manning, a health economist at the University of Chicago who worked on the report.

Dr. Daniel Einhorn says "the fact that people are still getting complications means we are not using our tools effectively enough," When people fail to follow their diet, exercise and drug treatment plans, the disease leads to complications that boost the total health bill to $57.1 billion. "Either the patient doesn't recognize they have it and complications develop, or they are not good about adhering to their doctor's orders," he said, adding, "We've got to do a better job of managing the disease." Dr. Einhorn serves on the board of the American Association of Clinical Endocrinologists.

Of course, it's the patient -- NOT the drugs they are using. It couldn't possibly be the drugs.

"Cure. Care. Commitment. These are the words we live by at the American Diabetes Association."

Blah, blah, blah......Those are the words you will hear when you call the ADA hotline and tell them their indifference and apathetic resolve to push for C-peptide trials is atrocious. (If you choose to do so, of course -- details to follow.)

After I blogged yesterday about the ADA colossal let-down -- I neglected to tell you how we can lend guidance to the ADA mission. It is apparent they do not know how to make good use of their 501(c)3 for the sake of cure, care and commitment to diabetes. No worries, ADA - millions of diabetics are here to help you understand our needs.

Contact the American Diabetes Association at 1-800-DIABETES and tell them:

ALLIE BEATTY of The Diabetes Blog told us that you were NOT going to encourage your big pharmaceutical sponsors to start clinical trials for C-peptide. We need this to prevent and reverse complications from the disease...

From there the floor is yours to proceed. Their hours of operation are Monday - Friday, 8:30 AM - 8 PM Eastern Standard Time.

Please call and tell them you want C-peptide. When labs began making insulin they didn't make it with C-peptide. You want it! You deserve it! But most importantly -- you need it!

Benfotiamine can help diabetics protect delicate microvessels. Much of the damage of diabetes is caused when glucose-derived compounds, called triosephosphates, accumulate in small vessels. Transketolase, turns these toxic compounds into harmless chemicals that can be removed from the body. benfotiamine increases transketolase activity, thus reducing or eliminating the complications associated with diabetes.

Administration of benfotiamine helped to prevent retinopathy in test subjects with diabetes. Study subjects who received benfotiamine for 36 weeks demonstrated completely normalized levels of damaging toxins in the retina, preventing or delaying the onset of diabetic retinopathy.

In a 24-week study, benfotiamine was shown to improve kidney function. This was shown by a 50% reduction of toxin levels in the kidneys, and a reduction in oxidative stress associated with diabetes. Subjects exhibited a 70-80% inhibition in the development of microalbuminuria, protein in the urine that serves as an early sign of kidney dysfunction.

Benfotiamine mitigates oxidative stress in the eyes, the kidneys, the heart, and even the brain that typically occur with diabetes. Researchers conclude that benfotiamine may offer critical protection for the delicate nerves of the eyes, the kidneys, the peripheral limbs, the heart and the brain by shielding them from damage caused by diabetes.

DexCom has developed a continuous glucose monitoring ("CGM") system that could be the next generation of aggressive control. The DexCom GCM is a device that measures glucose trends throughout the day, providing up to 288 glucose measurements every 24 hours.

A traditional glucose monitoring test -like finger sticks - leave gaps in time where you are uncertain as to your blood sugar reading. Continuous monitoring is different from traditional blood glucose monitoring because it affords a comprehensive picture of where your blood sugars are throughout the day and night. The trend reveals times throughout the day where your sugar may increase or decrease, as well as how fast it is happening. This trend information together with the glucose value shows you patterns and problems that traditional finger sticks cannot cover as thoroughly. CGM allows you to set a target range for your desired glucose. When your glucose goes above or below this range, an alert automatically lets you know.

A 2006 study showed that people who used this device were able to achieve a 23% decrease in time spent high and a 21% decrease in time spent low. After speaking with Dianne on the DexCom customer support line - she advised me that they are offering a $375 startup kit that has everything you need to get going. The Rechargeable STS Receiver has a sleek rounded design that can easily be carried with the carry case on both your belt or in a handbag. The STS Transmitter is lightweight and fits comfortably underneath clothing. The STS Sensor & Applicator is easy to insert and safe to use with no visible needles or exposed sharps. With this wireless system, no cables or wires will get in your way allowing you to Take Control and Live Uninterrupted.. Each sensor lasts for 3 days. A set of 5 sensors costs $175 and will last you approximately 15 days.

The annual cost of continuous glucose monitoring averages a ballpark figure of $4,258. Okay, sounds a little steep - but lean on Uncle Sam to offset the cost of the best control. Sounds like it might be time to open up a Flexible Spending Account and write-off the yearning for glucose precision.

Just like a referee to normalize play throughout the game - DiaKine Therapeutics is developing ways to normalize the body's immune system.

The new drugs modulate cytokines, part of the body's immune system, which mistakenly attack normal organs and tissue and cause diseases such as: diabetes, multiple sclerosis and inflammatory bowel disease. Research by Dr. Nadler and his collaborators published in 2006 showed that controlling certain cytokines can arrest the progression of, or reverse, type 1 diabetes in an animal model.

The company's first product, IsletLifeLSF Media 1 is designed to improve the viability and insulin producing capabilities of harvested islet cells prior to transplant. This would potentially improve the success rate of the procedure. Additional therapeutics under development by DiaKine include: adjunct therapy to islet cell transplants, halting the progression of type 1 diabetes in newly diagnosed adults, treatment and prevention of Latent Autoimmune Diabetes of Adults (LADA), treatment and prevention of insulin requiring type 2 diabetic, treatment and prevention of diabetes complications.

It all sounds like good stuff in the works. Keep an eye on the progress and press releases of DiaKine, as well as their research partner - the Diabetes Research Institute. A lot is happening these days. What else have you seen or heard about in the autoimmune arena?

On March 13, 2007, former President Bill Clinton joined global leaders to discuss ways to break the curve of the diabetes pandemic. The Global Changing Diabetes Leadership Forum held in New York City was hosted by Novo Nordisk and supported by the International Diabetes Federation (IDF). Yes, when people of this magnitude get together - you know it's serious business!

The forum convened the Masters of the Healthcare Universe to discuss ways to make diabetes a global health priority and ultimately, improve the way the disease is treated. The attendees were policymakers, patient organizations and healthcare professionals. It is estimated that 1 in 3 American children born in 2000 and beyond will develop type 2 diabetes. Worldwide, an estimated 246 million people have diabetes, and the number is expected to grow to 380 million within the next 20 years. A resolution today could prevent this harrowing disaster of tomorrow.

The Global Changing Diabetes Leadership Forum hopes to redefine healthcare around the needs of people with diabetes. Novo Nordisk has recognized that there is not a single answer to the diabetes pandemic. They seek to identify multiple actions to combat diabetes - from prevention to the treatment of serious complications. Lars Rebien Sørensen, president and CEO of Novo Nordisk says, . "Only by placing the person with diabetes at the center of care and changing how healthcare systems around the world approach the disease can this silent killer be defeated."

Novo Nordisk anticipates hosting a 2-day forum with this goal in mind. The forum will entail influential figures from around the world, participating in a series of workshops and dialogues designed to evoke a provocative debate about how to chart a course for changing diabetes management globally. For further details on the UN Resolution, please visit the unite for diabetes site.

Knocking out the gene for a peptide associated with insulin was shown to protect mice against the harmful effects of a high-fat diet. Urocortin 3 plays a role in the increased production of insulin in response to high caloric intake in animals.

Scientists found that by removing the urocortin 3 gene from mice, they did not develop the age-related insulin resistance and high blood sugar observed in the normal control mice. The metabolisms of normal mice were compared to the metabolisms of those without the urocortin 3 gene. When placed on a high caloric diet for three months, the mice without the urocortin 3 gene packed on the same amount of weight but had lower insulin levels. But these mice also had lower blood sugar, improved glucose tolerance curves and they did not develop the fatty livers the control mice experienced.

Scientists hypothesize that by curtailing the abnormally high insulin levels, they were able to manipulate insulin sensitivity and avoid some of the untoward consequences of the high food intake and weight gain. Like many of us diabetics already know too well - while insulin is effective at lowering blood sugar it also promotes fat storage. This is a natural protective response to prepare for times when food may not be available. When insulin is produced at too high a level for too long, the body becomes insulin resistant and blood sugar and certain blood lipids gradually creep up, which can cause progressive damage to multiple organs.

Urocortin 2 and urocortin 3 are part of the system that governs the body's response to insulin. Scientists already know that mice on a high-fat diet do better if either urocortin 2 or urocortin 3 is removed. Now they want to know if the mice will respond even better if both are missing. Such results may instruct us how best to develop therapeutic means to exploit these powerful effects.