How come type 2 diabetes does not affect all obese people? A study recently published in the Journal of Clinical Investigation may explain why. Adiponectin is a hormone that controls insulin sensitivity. Leptin is a hormone which lessens appetite. Too much adiponectin allows mice to store excess calories in fat tissue instead of in more dangerous areas -- the liver, heart or muscle tissue -- where extra fat may lead to inflammation, diabetes and heart disease. Unfortunately adiponectin levels decline as people get fatter. So researchers wondered "what if overeating mice had high levels of adiponectin?"
Researchers genetically engineered mice to produce lots of adiponectin and a lack of leptin. The mice overate and became obese, but their high levels of adiponectin enabled them to dump their fat into fat tissue, which has antidiabetic effects. Dr. Philipp Scherer, senior author, stated the inability to appropriately expand fat mass while overeating may be an underlying cause of insulin resistance, diabetes and cardiovascular disease. Low adiponectin levels don't allow fat cells to accept fat, so the fat builds up in inflammatory locations.
Considering 66 percent of American adults are overweight or obese, Dr. Scherer stated researchers need to find way to deposit extra calories in the least harmful places. He plans to investigate how to maximize good fat areas and shrink bad ones. This solution is disturbing to me -- don't we need to get rid of the fat in the first place? Read more in Health News Digest and check out Diane's recent post on upper body fat's link to insulin resistance.
1. Hi Bev Sklar,
GM insulin [lower blood glucose = store more fat] or HYPOglycaemic drugs [lower blood glucose = store more fat] or ADIPOnectin [lower blood glucose = store more fat] = less HYPERglycaemia, more obesity and reduced capacity to safely cope with relative-HYPOglycaemia & DISTRESS...
www.sim.org.tw/journal/jour17-2/04.PDF
UNdrugTREATED obesity is a lifestyle choice. UNdrugTREATED diabetes mellitus SHOULD be a lifestyle choice. UNdrugTREATED diabetes mellitus protects against the extraordinary challenges that arise from relative-HYPOglycaemia & DISTRESS ... and so to the degree that ADIPOnectin or HYPOglycaemic drugs or GM insulin prevent the symptoms of UNdrugTREATED diabetes mellitus [aka HYPERglycaemia] ... then it can be reasonably expected that (a) following such ANYdrugTREATED method [for preventing/reducing HYPERglycaemia] that diseases associated with HYPOglycaemia will increase rather than decrease; and (b) that even minor DISTRESS should rapidly initiate HYPERglycaemia, as a protective mechanism, in most UNdrugTREATED transgenic / ADIPOnectin-like treated mice; and (c) that inflammation [eg c/o bacteraemia] associated with relative HYPOglycaemia / DISTRESS will likely increase rather than decrease in most environments where DISTRESS is present...
www.pubmedcentral.nih.gov/picrender.fcgi?artid=1950456&blobtype=pdf
www.en.wikipedia.org/wiki/Bacteremia
Since approximately 1983 glucose-resistance associated with diabetes has been 'diluted' because GM insulin has been genetically modified to reduce insulin resistance and all traces of C-peptide have been removed. As more Diabetics of all types are treated with GM insulin the ability to 'type a Diabetic' via resistance to insulin becomes more challenging. UNdrugTREATED type 2 Diabetics certainly are the Masters of glucose-resistance [and Transient Supernormal Glycaemia 'TSG'] c/o their abundance of C-peptide and are all the more healthy for it ... BUT as various ANYdrugTREATED related steps are taken which deplete C-peptide availability from all Diabetics and create other ANYdrugTREATED combination methods eg including chromium to help 'force-feed' glucose aka "gavage" into cells that are already overflowing with glucose stores ... glucose-resistance is becoming futile...
www.thediabetesblog.com/2007/08/24/a-closer-look-at-chromium/#c6908012
The fact is that type 1a, 1b, 1.5, 2 & 2.5 (pregnancy) diabetes mellitus are all manifestations of the same cure ... for a the disease of "relative-HYPOglycaemia" [HYPERinsulinemia] all of which types [of diabetes] are currently being treated with GM insulin or other HYPOglycaemic substances...
Insulin autoimmune syndrome (IAS, Hirata disease) is considered to be the 3rd largest cause of relative HYPOglycaemia [endogenous HYPERinsulinemia] in Japan...
www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400010&lng=en&nrm=iso&tlng=en
A reduced C-peptide to insulin ratio leading to a lack of beneficial glucose resistance and consequent increase in attacks of relative HYPOglycaemia [endogenous HYPERinsulinemia] ...
www.thieme-connect.com/DOI/DOI?10.1055/s-2004-824862
Type 1a, 1b, 1.5, 2, 2.5 diabetes mellitus could / should all be graded as to the Diabetic's degree of GLUCOSE-resistance [rather than insulin resistance] eg the amount of glucose a Person can consume before their kidneys choose to make glucose overflow into their urine [because the GLUCOSE is being RESISTED].
Human Beings, including 'Diabetics' have ZERO requirement for eating GLUCOSE & glucose dense foods [aka carbohydrates] and certain Human Beings, including "type 2 Diabetics" actively demonstrate this with substantial & beneficial "GLUCOSE-RESISTANCE".
All 'Diabetics' have a glucose 'allergy' [aka glucose resistance] to a greater or lesser degree because the CARBOPHILIA fashion is to continue to eat glucose dense carbohydrates too often ie too often to be processed by a 'Diabetic's LIVER' that is already 'overflowing' with glycogen / glucose stores...
www.en.wikipedia.org/wiki/Gavage#Force-feeding_of_animals
www.en.wikipedia.org/wiki/Voluptuous
www.en.wikipedia.org/wiki/Fat_fetishism#Feederism
Diabetes aka HYPERglycaemia is a protective physiological response to the extraordinary dangers of relative HYPOglycaemia especially during periods of DISTRESS...
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1697832&blobtype=pdf
www.caep.ca/template.asp?id=F4E9FA1E16FC46FE9B3E80D8E5E86943
Relative HYPOglycaemia diseases [associated with 'diabetes mellitus'] start when 'treatments' including ignoring/fighting glucose-RESISTANCE continue/increase [such as those treatments which exclude eating less often].
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17659530&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
WHAT PREVENTS HYPERglycaemia...
Eat Less Often ... specifically ... Eat JUST clean water [zero % carbohydrate] between meals & eat ONLY when your blood glucose level, following your previous eat, has NATURALLY reduced to your chosen baseline blood glucose level [eg as related to the relative fuel demands of your particular activity level] and maintaining this habit, of 'supply & demand' glucose control, makes your prevention, of diabetes mellitus, sustainable.
...Warm thanks; Nick Dynes Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.TheDiabetesBlog.com @ 17:27hrs MON.27.AUG.2007 .
ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.
www.thediabetesblog.com/2007/04/19/no-food-no-problem
pps... FOR MORE related info please follow the links via...
http://www.thediabetesblog.com/2007/05/25/tv-causes-elevated-glucose-in-children/1#c6581479
www.thediabetesblog.com/2007/08/22/controlling-type-2-beyond-blood-sugar/1#c6889380
www.thediabetesblog.com/2007/08/23/once-upon-a-time-all-diabetes-was-treated-without-insulin/1#c6896177
ppps... Diabetes is NOT a disease ... diabetes is the CURE [for relative HYPOglycaemia]...
"Relative Hypoglycemia As A Cause Of Neuropsychiatric Illness" @ Journal Of The National Medical Association @ Harry M Salzer MD @ January 1966 @ Vol 58 @ Number 1.
Posted at 3:28PM on Aug 27th 2007 by Nicholas Dynes Gracey