1. I was taking actos and my doctor switched me avandia claiming better and safer results. It's very disappointing to find out I was put at greater risk from the change. Managing diabetes is hard enough without wondering about the medication and if the drug companies told the doctors to push it and if it has an actual benefit to you. This is definitely a wake up call!

Posted at 7:58AM on Jul 27th 2007 by Ralph

2. Hi Diane & Ralph,

Hearts sometimes need lots of glucose and when needs arise the body says 'quickly create a substantial increase in blood glucose to feed my heart cells at this time of need' and the body obeys [except, for example, when there is an ANYdrugTREATED state in the bloodstream which can prevent that natural heart-fuelling process [at its time of need] and consequently may forseeably result in?

CLUE... imagine You're a racing Driver and always need a 'fuel surge' for your racing car, when overtaking, but today one of your Crew has fitted a 'new' fuel saving device, to your engine, without your understanding how that device works]...

Insulin resistance [ie 'conditioned resistance' to a HYPOglycaemic hormone] is a curative process and is common to both type 1 & type 2 Diabetics.

Insulin resistance helps make glucose surges safer.

Insulin resistance protects the body from insulin surges and in particular the especially crucial CNS [brain & spinal cord] from HYPOglycaemia which can result from such insulin surges ... [without insulin resistance an insulin surge simply 'pumps' vital glucose fuel into the liver, fat & muscles and leaves a 'shortfall' for the CNS and some other type of 'fall' can easily result].

http://www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness/1#c5614998

Since the introduction of GM insulin, in around 1983, insulin resistance became more associated with type 2 diabetes, rather than type 1 diabetes, because type 2 Diabetics [before treatment with GM insulin] usually have an abundance of insulin & C-peptide and their bodies can safely run above normal glucose levels [HYPERglycaemia] in order to exert greater control over their fuel flow and help prevent HYPOglycaemia.

GM insulin lacks C-peptide. GM insulin often results in HYPOglycaemic unawareness because GM insulin has the capacity to circumvent insulin resistance. For those who chose GM insulin rather than natural and/or pig insulin ... insulin resistance is futile.

What if there is ZERO reference anywhere in the history of the world that provides Peer reviewed evidence that ANYdrugTREATED is better than UNdrugTREATED for any type 2 Diabetic?

Please Anyone identify just 1 such reference.

In the continued absence of any such reference it it reasonable to suppose that every type 2 Diabetic 'complication' arises as a result of the treatment of the 'insulin resistance' that was actually keeping type 2 Diabetics healthy in the first place.

www.sciencemag.org/cgi/content/abstract/317/5836/369

Presumably, in respect of 'Who is ultimately responsible for any consequential side effects?' ... such a reference should be producible by a GP or an MD or any other prescribing Physician treating their type 2 Diabetic Patient...

The Hippocratic Oath states: "To please no one will I prescribe a deadly drug nor give advice which may cause his death."

http://www.bmj.com/cgi/content/full/315/7116/1105?ijkey=4c5e5a57c2159aeebae55890c2d9c829fdf3c8a6&keytype2=tf_ipsecsha

BMJ 1997;315:1105-1106 (1 November)
Editorials

'... Why some cases of retinopathy worsen when diabetic control improves ... the rate of fall of blood glucose concentration and the accompanying reduction in blood flow have been thought to be the trigger ... This suggestion was supported by the finding of Grunwald et al, who showed a 20% reduction of blood flow when blood glucose concentrations fell from about 15 mmol/l to 8 mmol/l.'

As compared with the relative HIGH / JOY of UNdrugTREATED type 2 diabetes…

Where's the PROOF that type 2 diabetes ['insulin-resistant diabetes'] is anything other than beneficial? [when UNdrugTREATED]; and if that was other than clear...

Where's the PROOF, from your Physician, that type 2 diabetes ['insulin-resistant diabetes'] is anything other than beneficial? [when UNdrugTREATED].

Transient supernormal glycaemia 'TSG' occurs in every Human Being as a healthy and natural response to acute stress ['adaptative medicine'] … distributing glucose to nerve cells [without insulin receptors] and preventing 'HYPOs' [the real concern] … and may well increase HbA1c … so what? … when glucose levels surge up for a transient period [and then down again] an above average HgA1c can just as easily be viewed as a marker for a very healthy 'stress adapted' Human Being who has the benefit of being 'insulin-conservative' [ie a criteria for being labelled a 'type 1 Diabetic'] which protects INTRAcellular components of cells [with insulin receptors], from eg glycation of DNA, during periods of chronic stress.

If type 2 diabetes [UNdrugTREATED] is a health benefit ... as is proposed ... then most healthy People who have been free from diagnosis of 'above the average blood sugar level' would likely be living happy UNdrugTREATED lives with the benefit TSG... So here's an interesting fact about 7 million People who are 'too healthy to notice'...

'...The government estimates that more than 21 million Americans over age 20 have above normal blood glucose, but that at least a third don't know they have it...'

www.scrippsnews.com/node/24477

ie Apparently some 7 million Americans are adaptatively protected from numerous diseases [including cancer & Parkinsons] by way of 'insulin resistance' aka TSG aka HYPERglycaemia aka 'above normal blood sugar' aka diabetes [without even knowing how They are protected].

What is the most definitive study which substantiates the benefit of reducing HbA1c in drug/insulin treated acute&chronic 'insulin-resistant diabetes' [Type 2] … as compared with treatment-free [drug/insulin] acute&chronic 'insulin-resistant diabetes' [ie in a ZERO drug (repeat zero) treatment control Group ie UNdrugTREATED]? {ps please note the word written there says: "zero"} ie completely ignoring HbA1c value variability…

... Am seeking any 'Peer reviewed' study that clearly disassociates drug/insulin treatment from any changes in Patient behaviour [eg diet/exercise] and/or categorically proves that drug/insulin treated acute&chronic 'insulin-resistant diabetes' is healthier than doing absolutely nothing ['zero'] ie just accepting the higher HgA1c value and [possibly beneficial] blood glucose value [and likely beneficial "insulin resistance"]; and

What is the most definitive study which provides incontrovertible evidence that the apparent insulin receptor mediated down-regulation [in response to: transient supernormal glycaemia 'TSG'] is anything substantially other than a stress-adaptive mechanism of 'local' [on a cell-by-cell basis] intracellular cyto-protection from influx of excessive [blood] circulating glucose [ie homeostasis] eg cardio muscle protective?

... It is reasonable to propose that insulin receptor mediated down-regulation 'IRD' [aka "insulin resistance"] is primarily an adaptive [protective/regulatory/beneficial] reply to transient [and chronically repeated] oral indulgence/stress …

eg "...healthy young students were fed a very high fat diet containing egg yolks, heavy cream, and butter, and within 2 days all of the students had blood sugar levels high enough to be labelled diabetic..."
Sweeney J. Dietary factors that influence the dextrose tolerance test: A preliminary study. Archives of Internal Medicine 1927; 40:818.

TYPE 2 DIABETES WAS DISCOVERED BY ACCIDENT [c/o C-peptide] AND A NEW DIABETES NAME HAD TO BE CREATED WHEN ENOUGH ACCIDENTS HAD BEEN REALISED WITH INSULIN 'treatment'...

www.DrFuhrman.com
"…After World War I, when insulin was first discovered, the medical profession thought diabetes would be totally curable as a medical problem. Diabetes was believed to be due to insulin deficiency, and everyone thought that since insulin would now be given to patients there would be no more problems. It seemed this way for a few years, but terrible things started happening to patients with diabetes who were given insulin to control their blood sugar levels. They developed eye disease, kidney disease, and, most important, accelerating atherosclerosis leading to blood vessel disease and early heart attacks. Their problems were worse than ever. Decades later, when the insulin assay became available and doctors were able to measure insulin levels in their patients' bloodstreams, they found most interesting results: the insulin levels of type 1 (childhood-onset) diabetics were indeed low, but the levels in type 2 (adult-onset) diabetics were not only not low, but also were higher than those of people without diabetes. It became clear that type 2 diabetes is a disease of insulin resistance, not insulin deficiency. Type 2 diabetics produce plenty of insulin … I can only view today's treatment of diabetic patients as malpractice…"
(1995) Dr Joel Fuhrman [a board-certified Family Physician practising in Belle Mead, New Jersey who specialises in preventing and reversing chronic conditions of high blood sugar; Dr Fuhrman is an active staff member of Hunterdon Medical Centre and provides nutritionally oriented medical care to Patients as well as nutritional education to other Physicians; Author of "Fasting and Eating for Health" 'A Medical Doctor's Program for Conquering Disease'].

Warm thanks, Nick Dynes Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.TheDiabetesBlog.com @ 16:34hrs FRI.27.JUL.2007.

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

http://www.thediabetesblog.com/2007/04/19/no-food-no-problem

Posted at 12:33PM on Jul 27th 2007 by Nicholas Dynes Gracey