1. First off, there isn't going to be any study that says that insulin analogs are "better" just because that's a subjective term. There have been studies showing improved control, fewer allergies, and less resistance though, which I would think most people would consider better.

Secondly, hypoglycemia unawareness is basically a complication of control. You have good control, lows happen, lows happen, you become unaware over time. If you are high all the time, you are very aware of lows. So, I honestly feel hypo-unawareness is more common now because people are in better control.

Posted at 12:50AM on Jun 7th 2007 by Christine

2. I have to modify some of the thoughts that were expressed about Hypoglycemia Unawareness.
First, it is considered a feature of Autonomic Neuropathy as often seen in people with long standing T1DM.
Secondly, there may exist a correlation between the amount of the neurotransmitter, Norepinephrine that is available in the person with Diabetes who is experiencing Hypoglycemia Unawareness. This low level of Norepinephrine can account to not being able to feel the symptoms of low blood sugar.
Thirdly, if the person with T1DM is also on a Beta-Blocker, he/she will have "blunted symptoms" in being able to feel low blood sugar.
The non-availability of C-peptide was available with Animal-derived insulin but no longer available with the "new"-modified insulins may also account for the increase in people with Diabetes no longer being able to detect low blood sugar as well.
Mental Distraction might also be another contributing variable.
As you can see, the list is long with many factors that are possible contributing to Hypoglycemia Unawareness.
It is more complicated than a person being use to having high blood sugars all the time and now is more sensitive to low numbers.
Unfortunately there continues to be many cases of people experiencing Hypoglycemia Unawareness resulting in severe accidents, personal injury and worse.

Posted at 9:38AM on Jun 7th 2007 by BetterCell

3. Christine—

You seem to have two problems—one with semantics and the other with “feelings.”

(1) You state that “better” is a subjective term—and it is. Yet it is the very term used by the insulin cartel to promote rDNA Human insulin as it entered the competitive marketplace. It was “better” than animal insulin. Animal insulin was dirty—rDNA HI is “better.” Animal insulin was immunogenic—rDNA HI is “better.” When rDNA HI has been shown IN SCIENTIFIC STUDIES to be as immunogenic (for some diabetics) as animal insulin was (for some diabetics)—the veil is stripped from the insulin-cartel’s specious advertising claim. When animal insulin could claim 99% purity and rDNA HI could only achieve a 97% “purity” rate, the “better” label becomes disingenuous at best.

(2) Your “feeling” that hypo-unawareness is the result of “better control” within the population is based on what? Your love of Big Pharma and their skilled marketers? Your certainty that pharma and their medical enablers are more concerned about your health than your dollars? the gold star you received from your doctor for achieving such “good numbers?”

To put a chink in your “good control” theory, I present my own case—with attendant feelings. For more than 30 years, I used natural (animal) insulins to manage my disease. The “feelings” I had were sweats, tremors, hunger—and those “feelings” triggered an urgent need for food. Before bG monitors were even a gleam in the diabusiness eye, my “feelings” held me in good stead . . . never an episode of unconsciousness, never the need for outside intervention. A1c’s—which are the metric for assessing “good control”—were assessed infrequently, but my 5.5 readings should indicate I was not out of control. Quite frankly, I must state that while I did not enjoy these “feelings,” I was certainly appreciative that the “feelings” kept me out of danger and in control. Jump ahead to my interlude with “the latest, the greatest, rDNA Human insulin—it’s better” (so my doctor assured me). “Feelings” disappeared. While my monitor (upon which I became more and more dependent) told me my bG was low . . . my “feelings” did not. This interlude was short-lived, fortunately. Despite best efforts at achieving control with this peaky, unpredictable insulin, my A1c’s began to climb. Then I took a shot at pump therapy and Humalog/Novalog analogs. NO FEELINGS. bG monitoring became increasingly frequent. When my A1c reached 7.2 . . . I decided that as long as animal insulin was available and importable, I was better served using these products.

These products are becoming more difficult to obtain, and if Lilly/Novo achieve worldwide removal of natural insulins, some of us whose “feelings” are more fact-based than yours, will see our quality of life diminish, and our lives imperiled. Now maybe you think that old timers like me—who have used BOTH natural and synthetic products—are so antiquated and so unimportant that our “feelings” don’t matter. I beg to differ, and I’ll back my “feelings” with science—not industry-produced pseudoscience. Will you?

BTW, you did not state whether you are a long-time diabetic, MD, scientist, Eli Lilly cheerleader, ADA supporter. In other words—what do you bring to the table besides “feelings.”

Posted at 11:00AM on Jun 7th 2007 by Brent

4. I would ask first if Christine has used both natural and synthetic insulin and thus can speak subjectively to the merits/failings of each. Her second point addresses the diabetic control continuum: good control – low bGs – repeated low bGs – unawareness. Unfortunately, recently diagnosed diabetics ACCEPT this cycle as merely part of being a “good diabetic.” It seems that the reward for being a compliant, tightly-controlled diabetic is more frequent hypos and unanticipated encounters with unawareness. Some reward! Tragic outcomes may follow on the heels of unawareness (see Allie’s post on Mr. Universe). Sadly, hypo unawareness spawned the “Dead-in-bed” syndrome.

Posted at 12:25PM on Jun 7th 2007 by Melody

5. Hi Christine,

In respect of your post #1 and comment "less resistance"
http://www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness/#comments

Since when is "less resistance" a good thing?

If GM insulin is super-efficient at 'pumping' sugar out of the bloodstream and into the intracellular spaces of the LIVER & WAT [White Adipose Tissue] cells ... via GM obedient insulin receptors ... the net result is a prompt FALL in blood sugar [bs] and a potential shortage of sugar available for delivery to the brain/CNS.

Insulin "resistance" [allegedly 'disobedient insulin receptors'] can be a very good safety mechanism for keeping People ALIVE. The insulin resistance should be celebrated by Type 2 Diabetics and Type 1 Diabetics.

If 'high' bs is a concern for those blessed with insulin 'resistance'(why?) ... increasingly reduce the amount of carbohydrates swallowed. AKA a LOW [sub 15%] carbohydrate Diet eg Dr Fuhrman's [cure Type2 & reduce Type1 GM dose by half]; or Dr Bernstein's [probably cure Type2 & reduce Type1 GM dose by half]; or Dr Atkins' [possibly cure Type2 & reduce Type1 GM dose by half].

In an UNdrugTREATED Human Being ... Transient Super Glycaemia [TSG] almost always comes to the rescue [via increased release of glucose from the liver into the bloodstream + 'insulin resistance'] when there is any distressful short term event and TSG should always be welcomed because to do the opposite [ie set up conditions for Transient HYPOglycaemia (THG)] can be fatal.

If the textbook or research currently published, on the subject of diabetes ['raised' bs], was entirely correct that disease would already have been cured / eradicated ... which logic suggests [given the state of diabetes treatment] that virtually every current textbook premise & treatment [re diabetes] really is "incorrect".

In the presence of C-peptide / 'Insulin Resistance' [aka protection from excess insulin] ... The FMCSA 140-200mg/dl bs premise may be correct:-
http://www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker

In the presence of C-peptide / 'Insulin Resistance' [aka protection from excess insulin] ... The premise of an indefinite Honeymoon Period may be correct:-
http://www.thediabetesblog.com/2007/04/03/the-honeymoon-period/

Warm thanks, Nick Dynes Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.TheDiabetesBlog.com @ 17:27hrs THU.07.JUN.2007.

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 12:57PM on Jun 7th 2007 by Nicholas Dynes Gracey

6. Nicholas, your comments are a bit too technical for me to comprehend. My observation, however, is this: increasing numbers of T1's are being "supplemented" with oral medications; and T2's are being more quickly urged to include insulin as part of their treatment--in addition to orals. These treatments seem to be the medical answer to "insulin resistance." Strange, there's never a report of AAI testing . . . just keep adding drugs and increase the 'cost of diabetes.'

Posted at 3:36PM on Jun 7th 2007 by Melody Hoadley

7. Hi Melody,

In respect of your post #6 and comment "insulin resistance"
http://www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness/#comments

Glucose is an emergency fuel ... D3HydroxyButyricAcid is the body's normal fuel ... "insulin resistance" protects the intracellular contents of every cell having an insulin receptor from sudden rises in blood glucose. [HbA1c measures bs outside the cells NOT inside the cells]...

... sudden rises in blood sugar following periods of HYPOglycaemia can have VERY negative effects IF the glucose can get out of the bloodstream and into the cells...
http://medindia.net/news/view_news_main.asp?x=19870

"insulin resistance" prevents HYPOglycaemia ...

Until PROOF exists to the contrary ... The FMCSA 140-200mg/dl blood sugar level recommendation should be every Diabetic's target range c/o basal GM insulin or any other DRUG:-
http://www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker
[anything lower should be entirely via dietary control eg a LOW carbohydrate Diet as per post #5 above].

Warm thanks; Nick

ps AIS 'autoimmune insulin syndrome' where insulin suddenly disassociates from its antibody binding and causes sudden HYPOglycemia is rarely discussed.

pps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 6:35PM on Jun 7th 2007 by Nicholas Dynes Gracey

8. Nick—

I appreciate your response on “insulin resistance.” This is a phenomenon that I have been trying to satisfactorily explain to myself for years, and you have shed more light on the problem. “Insulin resistance” implies that the cells of the body in some way are preventing insulin acceptance. If metabolic processes of the body (i.e. antibodies, hormones, etc) are interfering with the insulin, then we’re talking about “insulin capture.”
Because there have been no true, workable basal insulins available since Beef Ultralente was removed from the marketplace, I have taken multiple shots of Regular Purified Pork or Bovine insulin. The phenomenon that exists in this type of protocol include overlapping pharmacokinetics and dynamics from injection to injection that may affect ‘insulin resistance;’ (in other words, if the tail of one shot does not overlap the beginning activity of a succeeding shot, it is hard to explain whether the body just “ran out of insulin” or recognizes in some manner the absence of insulin and responds with “resistance.”) If it were just a matter of getting insulin into the system more quickly, then taking a shot of Humalog would lower bG quickly, but that doesn’t happen. A shot of Humalog (in this instance) does not lower bGs at the same equivalency rate as seen in response to excess calories.

Another phenomenon that I experience with regularity results from exercise, in its many forms, and the role it plays in “insulin resistance.” Doctors had always told me that the influence exercise has on bG levels is finite—usually about 3 to 4 hours. My experience has been that, based on duration and intensity, exercise can have definite impact on insulin “usage” for 8 hours and longer. This would help to explain some “sudden death” and “dead-in-bed-syndrome” incidents occurring after heavy exercise. In some instances, resistance-training can actually INCREASE bG levels. In fact, I have found Far Infrared Sauna treatments will also increase bG levels for a short period of time. The theory of antibody capture of insulin leading to significant lows becomes a question of ‘the chicken or the egg.’

The phenomena related to “rebound” and “dawn phenomenon” are not readily explained in terms of “insulin resistance.” My bG (with equivalent units of insulin) is much harder to control in the morning hours after breakfast, with the same type/quantity of carbs when compared with results observed later in the day. At the same time, once a low has occurred, and the endocrine system has responded appropriately with cortical steroids, epinephrine and adrenaline, the interplay between what is called “insulin resistance” and liver enzyme release leading to increased available “food” for the body has always intrigued me. Lows, as you know, can upset one’s bG management for 48 hours or longer.

The last time I talked with a “knowledgeable” diabetic specialist, he thought ‘rebound’ and ‘dawn phenomenon’ should be as easy to explain as finding your wife’s best friend beside you in bed the next morning.

Back in the mid-1960s, I was a medical guinea pig, allowing doctors to explore my “brittle” diabetes with radioactive insulin. They evolved a theory that actually had little impact on my treatment. But, I was thinking of all the ‘theories’ that have evolved about many of the idiosyncracies of this highly individual disease. Wouldn’t it be beneficial if scientific theorists could collaboratively share information and perhaps turn a few theories into useful, workable “truths” while de-bunking and discarding interesting but insignificant minutiae?

Posted at 9:03AM on Jun 8th 2007 by Melody Hoadley

9. Hi Melody,

In respect of your post #8 and comment re. cell receptor "insulin resistance" as distinct from extracellular "insulin capture/release"
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglyce

Your life seems to have a great deal of 'insulin' chasing 'carbohydrates'. Chasing them too much AND experiencing HYPOglycaemia? Please check the textbook definition of the 'disease' alleged on this forum ... one that can make You thirsty & urinate glucose or one that can cause fatal HYPOglycaemia and cumulative side-effects related to repetitive recovery from HYPOglycaemia?

Insulin's primary function appears to be LIVER regulation. A BASAL [probably much lower than expected] level, of insulin, prevents DKA ... which is VERY very different from ketosis [aka 'fat shedding'].

There's a finite amount of glucose the white fat cells [and other cells with 'fine tuning' insulin receptors] will take before saying 'enough is enough' [care of ADAPTATIVE insulin resistance] and the excess is simply spilled to urine.

"insulin resistance" should be cherished.

Why have breakfast? Why have lunch? What do You think body fat is for?
http://www.thediabetesblog.com/2007/04/19/no-food-no-problem

Until PROOF exists to the contrary ... The FMCSA 140-200mg/dl blood sugar level recommendation should be every Diabetic's target range c/o basal GM insulin or any other DRUG:-
http://www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker
[anything lower should be entirely via dietary control eg a LOW carbohydrate Diet as per post #5 above].

Exercise is great but often triggers TSG to provide that emergency sugar fuel "glucose" from the liver ... and trying to shut down that flow with GM insulin [which appears to compromise insulin resistance] is VERY counter-productive because control of that surge is the job of the insulin receptors.

Independent Researchers are very rare ... most are 'in jobs' and paid to say what They say ... BUT here's a rare example of an independent Authority in a field [related to diabetes] ... Professor Joel Kauffman; please click on this > ... http://www.jpands.org/vol12no1/kauffman.pdf and study/comment the GRAPHS on page 3 [before taking statin DRUGS].

Warm thanks; Nick

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 11:51AM on Jun 8th 2007 by Nicholas Dynes Gracey

10. Hello Melody and Nick............
Just a few comments based on what I have just read from your input.
For myself, I find that doing weight-resistance exercise(and I do it everyday in addition to Martial Arts) will LOWER my blood sugars by about 70mg/dl within a 30-60min. time frame.
So, Melody this supports your feeling about individual "differences" in T1DM.
I am also curious Melody, if you have tried to incorporate either Glargine or Levemir
as your Basals in addition to your Animal-Derived short-acting Insulin?
Nicholas.......the reason I feel that Melody and others(Myself) are "chasing carbohydrate intake" is because, very simply we are all on exogenous insulin which does not have the interplay with counter-regulatory hormones that one would find in a person w/o T1DM.

Posted at 1:22PM on Jun 8th 2007 by BetterCell

11. Nicholas--

Could you go to husband's book site, and contact me through the webmaster there?

http://www.tooprofitabletocure.com

Posted at 8:08AM on Jun 9th 2007 by Melody Hoadley

12. Hi BetterCell,

In respect of your post #10 and comment re. exercise to "LOWER my blood sugars by about 70mg/dl within a 30-60min. time frame"
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglyce

Your life seems to have a great deal of 'exercise' chasing 'carbohydrates'. Chasing them too much AND too often experiencing HYPOglycaemia? Please check the textbook definition of the 'disease' alleged on this forum ... one that can make You thirsty & urinate glucose [and needing a rest and/or rest from FOOD] or one that can cause fatal HYPOglycaemia and cumulative side-effects related to repetitive recovery from 'DRUG' / FOOD induced ... HYPOglycaemia?

Insulin's primary function appears to be LIVER regulation. A BASAL [probably much lower than expected] level, of insulin, prevents DKA [with confidence] ... which is VERY very different from ketosis [aka 'fat shedding' aka 'fat metabolism' aka 'fat catabolism'].

There's a finite amount of glucose that healthy white fat cells [and other cells with 'fine tuning' insulin receptors] will 'intake' before saying 'enough is enough' [care of ADAPTATIVE insulin resistance] and the excess is simply spilled to urine.

"insulin resistance" can save your life.

Why exercise to lower blood sugar? Healthy exercise either raises blood sugar [TSG] or keeps blood sugar at the same level. Healthy exercise also metabolises FAT as a fuel.

If your chosen exercise 'will LOWER blood sugars by about 70mg/dl within a 30-60min. time frame' ... that says your blood sugars were approx and/or at least 70mg/dl too high in the first place and your exercise is being adopted like a 'magic' DRUG 'chasing carbohydrates' ... with ever potential HYPOglycaemic outcome.

ANYdrugTREATED Type 1 & Type 2 Diabetics have above 'average' blood sugar because of excessive carbohydrate consumption [for their particular needs]. The exercise link is a MYTH. A dangerous myth that often leads to dangerous 'raceism' [http://en.wikipedia.org/wiki/Racism] and even more dangerous HYPOglycaemia.

Why have breakfast? Why have lunch? What do You think body fat is for? Why do You think every Human Being's LIVER produces ketones when bs and insulin levels are 'healthily low'?
http://www.thediabetesblog.com/2007/04/19/no-food-no-problem

Until PROOF exists to the contrary ... The FMCSA 140-200mg/dl blood sugar level recommendation should be every Diabetic's target range c/o basal GM insulin or any other DRUG:-
www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker
[anything lower should be ENTIRELY via dietary control eg a LOW carbohydrate Diet as per post #5 above].

Exercise is great but often triggers 'Transient Super Glycaemia' [TSG] to provide that emergency sugar fuel "glucose" from the liver ... and trying to shut down that 'emergency fuel' flow with 'exercise' or other 'DRUGS' including GM insulin [which appear/s to compromise insulin resistance] is VERY counter-productive because control of that bs surge is the job of the insulin receptors.

Courageous 'self-experimenting' intelligent Humans are very rare ... most Humans are 'in jobs' and paid to say what They say [with ever diminishing courage/love] ... BUT here's a rare example of an intelligent independent Human with courage a plenty [in a field increasingly related to diabetes] ... 'funniinnit'; please click on this > ... http://www.youtube.com/watch?v=7KD7omFDAKo and study/comment upon statins effects on love [before taking statin DRUGS].

Warm thanks; Nick

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 4:09PM on Jun 9th 2007 by Nicholas Dynes Gracey

13. Nicholas..........
T1DM is a Disease that is influenced by many variables. It is not an "exact science" even w/those who wear a Insulin Pump. Complications because of T1DM still occur.
" Your life seems to have a great deal of 'exercise' chasing 'carbohydrates'. Chasing them too much AND too often experiencing HYPOglycaemia?"

In T1DM the ways to modify blood sugar levels ARE exercise, carbohydrate intake and the use of exogenous insulin.
So of course, I am as you said, "chasing carbohydrates" since they convert to sugar, which people who have T1DM and who no longer have endogenous insulin production must do. It would be "easier" with a pump, but still not perfect.
Exercise rather than the taking of additional insulin is a better form of maintenance, since there are additional benefits to the whole body.

Posted at 10:48AM on Jun 10th 2007 by BetterCell

14. Hi BetterCell,

In respect of your post #10 and comment re. "Exercise rather than the taking of additional insulin is a better form of maintenance, since there are additional benefits to the whole body"
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness

Where is the evidence that exercise, which lowers blood sugars, has overall benefits or lowers the overall death rate?

Why exercise to lower blood sugar? Healthy exercise either raises blood sugar aka Transient Super Glycaemia [TSG] or keeps blood sugar at substantially the same level. Healthy exercise also metabolises FAT as a fuel.

ANYdrugTREATED Type 1 & Type 2 Diabetics have above 'average' blood sugar because of excessive carbohydrate consumption [for their particular needs]. The exercise link is a MYTH.

If your chosen exercise 'will LOWER blood sugars [bs] by about 70mg/dl within a 30-60min. time frame' ... that says your blood sugars were approx and/or at least 70mg/dl too high [ie approx and/or more than DOUBLE the 'recommended' bs level] in the first place and your chosen exercise is being adopted like a 'magic' DRUG 'chasing carbohydrates' ... with ever potential HYPOglycaemic outcome eg...
http://ajpendo.physiology.org/cgi/content/full/290/6/E1331

There is evidence that lowering insulin levels can be protective eg...
http://www.docguide.com/news/content.nsf/news/852571020057CCF6852572F4006A7661

Why have breakfast? Why have snacks? Why have lunch? Why have snacks? [all of which raise insulin demands] What do You think 'body fat' is for? Why do You think every Human Being's LIVER produces ketones [D3HBA] (?) when blood sugar [bs] and insulin levels are 'healthily low' eg...
http://www.thediabetesblog.com/2007/04/19/no-food-no-problem

"Exercise your FAT"

Warm thanks; Nick

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 12:01PM on Jun 10th 2007 by Nicholas Dynes Gracey

15. Nick.....
By saying that exercise lowers my Glucose level to 70mg/dl within 30-60 min. does not imply that my blood sugars were 70mg/dl too high.
That is an implication that you are making, which bears no truth in Science or Reality.

Posted at 3:16PM on Jun 10th 2007 by BetterCell

16. Hi BetterCell,

In respect of your post #2, #10, #13 & #15 and comment re. "Unfortunately there continues to be many cases of people experiencing Hypoglycemia Unawareness resulting in severe accidents, personal injury and worse..."
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness/

It is important to remember that Diabetics are often prescribed drugs in addition to GM insulin. All drugs have side effects. Some side effects have a negative effect upon the functioning of the human brain.

What is increasingly clear is that DRUGS such as statins can effect memory [www.spacedoc.net] and that all Diabetics can suffer from HYPOglycaemia ... and many Diabetics drive cars and even more go to bed regularly [re that GM insulin related 'syndrome'] and that just one memory mistake with a bs reading can have negative health consequences for more than 1 Person.

Your post #10 states: "For myself, I find that doing weight-resistance exercise(and I do it everyday in addition to Martial Arts) will LOWER my blood sugars by about 70mg/dl within a 30-60min. time frame."

Your post #15 states: "By saying that exercise lowers my Glucose level to 70mg/dl within 30-60 min. does not imply that my blood sugars were 70mg/dl too high."

"will LOWER my blood sugars by about 70mg/dl" & "that exercise lowers my Glucose level to 70mg/dl" are 2 DIFFERENT statements.

Your 'change' in your 'edited' post #15 assumption ... is that your fall in bs is limited to being lowered "to" 70mg/dl. There are many scientifically documented reasons for that 'falling bs' continuing to fall below 70mg/dl.

An honest interpretation to your post #10 is that there is a very real possibility of your bs level being reduced BELOW 70mg/dl.

It is entirely possible to have a normal blood sugar level of 70mg/dl. eg...
http://www.vanderbiltchildrens.com/interior.php?mid=753

HYPOglycaemia Unawareness ... can be dangerous or fatal if ANYdrugTREATMENT that is capable of reducing "blood sugars by about 70mg/dl within a 30-60min. time frame" is commenced when blood sugar level is 140mg/dl or less.

HYPOglycaemia Unawareness ... can be dangerous or fatal if a chosen exercise that is capable of reducing "blood sugars by about 70mg/dl within a 30-60min. time frame" is commenced when blood sugar level is 140mg/dl or less.

If your chosen exercise 'will LOWER blood sugars [bs] by about 70mg/dl within a 30-60min. time frame' ... TO SAFELY SURVIVE THAT REGIME ... that says your blood sugars were approx and/or at least 70mg/dl too high [ie approx and/or more than DOUBLE the 'recommended' optimum bs level] in the first place and your chosen exercise is being adopted like a 'magic' DRUG 'chasing carbohydrates' ... with ever potential HYPOglycaemic outcome eg...
http://ajpendo.physiology.org/cgi/content/full/290/6/E1331

Careful reading of the scientific reference above should help explain reasons for the reality of your past experiences of "broken bones" & "falling" as alleged in your previous posts ... ie in relation to your CHOSEN practice of a form of exercise capable of lowering your bs of at least "70mg/dl within a 30-60min. time frame".

ANYdrugTREATED Type 1 & Type 2 Diabetics have above 'average' blood sugar because of excessive carbohydrate consumption [for their particular needs]. The exercise link is a MYTH. A dangerous myth that often leads to dangerous 'raceism' [http://en.wikipedia.org/wiki/Racism] and even more dangerous HYPOglycaemia.

Where is the evidence that exercise, which lowers blood sugars, has overall benefits or lowers the overall death rate?

Why exercise to lower blood sugar? Healthy exercise either raises blood sugar aka Transient Super Glycaemia [TSG] or keeps blood sugar at substantially the same level. Healthy exercise also metabolises FAT as a fuel.

"Exercise your FAT & stabilise your BS"

Warm thanks; Nick

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 5:33PM on Jun 10th 2007 by Nicholas Dynes Gracey

17. Hi Melody,

In respect of your post #11 and comment: "http://www.tooprofitabletocure.com"
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness/#comments
and your post #8 comment [from an MD]: "if the diabetic in my office a few minutes ago "needed" a statin, an SSRI, and BP med, then the diabetic I am now treating may also "benefit" by the same prescribing recommendations."
www.thediabetesblog.com/2007/06/05/charges-dropped-against-mr-universe/#comments

Glucose is an emergency fuel ...

D3HydroxyButyricAcid is the body's normal fuel ...

"insulin resistance" protects the intracellular contents of every cell having an insulin receptor from sudden rises in blood glucose. [HbA1c measures bs outside the cells NOT inside the cells]...

... sudden rises in blood sugar following periods of HYPOglycaemia can have VERY negative effects IF the glucose can get out of the bloodstream and into the cells...
http://medindia.net/news/view_news_main.asp?x=19870

"insulin resistance" prevents HYPOglycaemia ...

Until PROOF exists to the contrary ... The FMCSA 140-200mg/dl blood sugar level recommendation should be every Diabetic's target range c/o basal GM insulin or any other DRUG:-
http://www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker

Any bs lower than the FMCSA recommendation should be entirely via dietary control ie If 'high' bs is a concern for those blessed with insulin 'resistance'(why?) ... increasingly reduce the amount of carbohydrates swallowed. AKA a LOW [sub 15%] carbohydrate Diet eg Dr Fuhrman's [cure Type2 & reduce Type1 GM dose by half]; or Dr Bernstein's [probably cure Type2 & reduce Type1 GM dose by half]; or Dr Atkins' [possibly cure Type2 & reduce Type1 GM dose by half].

Mr. Universe apparently had HYPOglycaemia and most of the 'Onlookers' had UNawareness.

Please discuss the source, the cause and the role of HYPOglycaemia as associated with the 'heuristic symptoms' that MD's are 'treating' with "...a statin, an SSRI, and BP med..."

Warm thanks; Nick

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 9:00AM on Jun 13th 2007 by Nicholas Dynes Gracey

18. Hi Allie & Brent;

potentially 'OVERdosing' or potentially 'UNDERdosing' insulin or GM insulin ... (A) Which is SAFER; (B) Why does the human body sometimes appear to have an 'allergy' to human insulin; and (C) What is the optimum 'self-help' strategy for achieving an indefinite "Honeymoon Period" and/or maybe a "2nd Honeymoon Period" aka 'beta-islet cell regeneration'?

(1) re Allie's blog & Brent's comment #3 relating to that blog...
www.thediabetesblog.com/2007/06/06/victims-of-circumstance-in-hypoglycemic-unawareness
... "To put a chink in your “good control” theory, I present my own case—with attendant feelings. For more than 30 years, I used natural (animal) insulins to manage my disease. The “feelings” I had were sweats, tremors, hunger—and those “feelings” triggered an urgent need for food. Before bG monitors were even a gleam in the diabusiness eye, my “feelings” held me in good stead . . . never an episode of unconsciousness, never the need for outside intervention. A1c’s—which are the metric for assessing “good control”—were assessed infrequently, but my 5.5 readings should indicate I was not out of control. Quite frankly, I must state that while I did not enjoy these “feelings,” I was certainly appreciative that the “feelings” kept me out of danger and in control. Jump ahead to my interlude with “the latest, the greatest, rDNA Human insulin—it’s better” (so my doctor assured me). “Feelings” disappeared. While my monitor (upon which I became more and more dependent) told me my bG was low . . . my “feelings” did not. This interlude was short-lived, fortunately. Despite best efforts at achieving control with this peaky, unpredictable insulin, my A1c’s began to climb. Then I took a shot at pump therapy and Humalog/Novalog analogs. NO FEELINGS. bG monitoring became increasingly frequent. When my A1c reached 7.2 . . . I decided that as long as animal insulin was available and importable, I was better served using these products."

(2) re Allie's blog & Scott's comment #1 relating to that blog...
www.thediabetesblog.com/2007/04/03/the-honeymoon-period
... "But I think he has one undeniable truth, and that is the law of small numbers, namely that by minimizing the amount of insulin required, the patient also reduces the possibility for errors, and if errors occur, they are likely to be less severe ... but the basic idea is the same: insulin is not an easy medicine to use, therefore the idea of reducing our need for it is probably a goal that is worthy of pursuit."

(3) re Allie's blog & Scott's comment #3 relating to that blog...
www.thediabetesblog.com/2007/06/17/the-rising-prices-of-insulin
... "However, the biggest question was why are we treating patients with "human" insulin when type 1 diabetes is known to be the result of a human allergy to "human" insulin?"

AND another interesting question...

What about treating Patients with the absolute MINIMUM amount of GM insulin ... when type 1 diabetes is known to be the result of a human allergy to "human" insulin?

AND because Scott's question has inspired this question which in my opinion is one of the most fundamental questions ever to be asked about type 1 diabetes ... please allow my asking similar related questions, yet again, so We can really focus on quickly finding the right answers...

What about treating Patients [and especially newly diagnosed Patients still in their "Honeymoon Period"] with the ABSOLUTE minimum amount of GM insulin & carbohydrates ... when type 1 diabetes so often and so certainly appears to be an ALLERGY to 'excess' GM insulin [... or is it a transient ALLERGY to carbohydrates related to the inherent capacity of carbohydrates to induce high > low bs patterns even in 'normal' People?].

Brent's experience appears to be a raised level of normal and/or raised mean glycaemia marked by raised HbA1c ... irrespective of which Brent reports more insulin-induced HYPOglycaemia events with GM insulin than with animal derived insulin. For Brent, who has had experience of both animal derived insulin & GM insulin, it is the latter that appears to be more 'efficient' at removing glucose availability, from Brent's brain, even though his mean blood sugar level apparently remains high enough to raise his HbA1c measurements. If Brent adopted the absolute minimum GM insulin dose to prevent 'ketoACIDosis' [ie with a focus upon adopting GM insulin primarily for maintaining his pH above 7.1] ... then GM insulin-induced HYPOglycaemia events may be reduced? AND then Brent and other type 1 & type 2 Diabetics [in a similar position] could focus much more of their energy upon 'HbA1c control' by means of, focus upon, dietary control of carbohydrate ingestion.

Here's some related possibilities which may favour protection and/or recovery of pancreatic beta-cells by reducing GM insulin 'OVERdosing' at all times and especially during the "Honeymoon Period" ...

There is a 'middle ground' of SAFELY reducing insulin by SAFELY skipping meals / snacks rather than simply 'skipping GM insulin'...

Careful study of scientific literature provides scientific EVIDENCE that the substantial DAILY danger from insulin is from insulin OVERdosing [or does that usually 'flow from' carbohydrate OVERdosing?].

www.thediabetesblog.com/2007/04/19/no-food-no-problem
Every Diabetic has the right to substantially lower GM insulin dosage, on any given DAY basis [to their preferred 'skip meals' dosage] and/or skip meals and reduce their body fat % by that SAFE means [aka 'water fasting']. It is perfectly SAFE for a type 1 diabetic or type 2 diabetic to skip meals or eat just 1 healthy meal per day. Every Diabetic has the right to eat just 1 meal a day and to know that it is a FACT that is scientifically proven to be SAFE to lower GM insulin dosage in order to SAFELY skip meals and/or safely water fast...
http://www.thediabetesblog.com/2007/04/19/no-food-no-problem

HYPOglycaemia IS the most substantial of any 'Diabetic DISEASE' ...

How may the human body 'protecting itself from HYPOglycaemia' be related to the onset of type 1 diabetes and/or a reduction in a potentially indefinite "Honeymoon Period"?

PRE 'Diabetic Growing Children' aka 'Juvenile Onset Diabetics' are particularly venerable to HYPOglycaemia [related to 'fuelling' growth requirements] and it is reasonable to suppose that their bodies [including their immune system] may 'work overtime' to prevent HYPOglycaemia [possibly resulting from 'excess pancreatic (endogenous) insulin' and/or immediately upon treatment 'excess (exogenous) GM insulin'] which is often associated with eating carbohydrates... 'Too Much And Or Too Often' ... often associated with distress stimulated release of glucagon [which protects against HYPOglycaemia following insulin surges following prolonged stress (aka distress) including eating carbohydrates and/or GM insulin treatment ... 'Too Much And Or Too Often'].

Glucose = emergency fuel = very positive for emergency refuelling [as long as that emergency is other than HYPOglycaemia].

A "spike" or transient super glycaemia [TSG] is a healthy natural response to stress including eating excessively [as long as that stress is other than HYPOglycaemia].

D3HydroxyButyricAcid [D3HBA] is the body's normal fuel = very positive in normal situations including being free from emergencies [and protects from HYPOglycaemia]. D3HBA can be increased by skipping meals and/or substantially reducing the carbohydrate %percentage% of any given meal.

"insulin resistance" & "impaired glucose tolerance" by way of insulin receptors protects the intracellular contents of every cell [having an insulin receptor] from sudden rises / spikes of glucose. [HbA1c measures bs outside the cells NOT inside the cells]...

... However ... sudden rises in blood sugar following periods of HYPOglycaemia can have VERY negative effects IF the excess glucose [contained within the 'inside' of the bloodstream] can get out of the bloodstream and into the 'inside' of the cells ... too suddenly ... as outlined by this ORIGINAL research ...
http://www.jci.org/cgi/content/full/117/4/910
AND the commentary upon the abovementioned original research is also worth a read ...
www.medindia.net/news/view_news_main.asp?x=19870

"insulin receptors" can resist sudden surges of glucose into the cells and so help to prevent HYPOglycaemia ...

There is increasing evidence that 'tightly controlled numbers', 'low bs' and associated transient HYPOglycaemia should be of far far greater concern than transient 'bs spikes' / transient HYPERglycaemia ... Please read this ORIGINAL research to see why TSG is perfectly healthy ...
http://care.diabetesjournals.org/cgi/content/full/29/7/1486?ijkey=94e3c9770f5c4db2a7b913326420344c278b4260

Until PROOF exists to the contrary ... The FMCSA 140-200mg/dl blood sugar level recommendation should be every Diabetic's target range c/o basal GM insulin or any other DRUG:-
www.thediabetesblog.com/2007/03/29/my-friend-jeff-the-trucker

Any bs lower than the FMCSA recommendation should be entirely via dietary control ie If 'high' bs is a concern for those blessed with 'insulin resistant receptors' (why?) ... increasingly reduce the amount of carbohydrates swallowed. AKA a LOW [sub15 %] carbohydrate Diet eg Dr Joel Fuhrman's [cure Type2 & reduce Type1 GM dose by half]; or Dr Richard K Bernstein's [probably cure Type2 & reduce Type1 GM dose by half]; or Dr Robert Atkins' [possibly cure Type2 & reduce Type1 GM dose by half].

Carbohydrates = glucose [lots of it]

Peanut allergy = 1 peanut = potentially fatal.

'Carbohydrate allergy' [aka 'insulin allergy'] = glucose = diabetes [alive and GM insulin kicking].

There is already evidence that lowering insulin levels can be protective eg...
www.docguide.com/news/content.nsf/news/852571020057CCF6852572F4006A7661
and there is increasing evidence that every Diabetic's primary concern should be that insulin levels can & should be lowered by focussing upon encouraging "KETOSIS" and controlling 'ketoACIDosis' rather than chasing questionable 'HYPOglycaemia UNawareness levels' of low blood sugar [bs] eg...
www.blackwell-synergy.com/doi/abs/10.1111/j.1399-5448.2007.00240.x

When have Diabetics ever considered how much easier an ultra low carbohydrate [sub15 %] diet is as compared to a zero nut diet?

Carbophiles may reasonably be described as craving eating emergency fuel to repetitively create emergency stimulation via 'repetitive HYPOglycaemia' ...
www.obesityresearch.org/cgi/content/abstract/3/suppl_4/477S

Why have breakfast? Why have snacks? Why have lunch? Why have snacks? What do You think 'body fat' is for? Why do You think every Human Being's LIVER produces "KETONES" [especially 'D3HBA'] when blood sugar [bs] AND insulin levels are 'healthily low'? 1 meal a day is enough for Anyone Who can chew...
www.thediabetesblog.com/2007/04/19/no-food-no-problem

"Say NO to Carbophilia"

AND WHEN YOU HAVE YOUR '3 COURSE MEAL' ...
PLEASE REMEMBER WHERE THE 'SWEET' COMES?

Warm thanks, Nick Dynes Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian c/o www.TheDiabetesBlog.com @ 19:23hrs MON.25.JUN.2007.

ps... Diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

Posted at 3:53PM on Jun 25th 2007 by Nicholas Dynes Gracey