I love you, you're perfect, now change
Posted May 24th 2007 10:19PM by Allie Beatty
Filed under: Type 1, Type 2, Childhood, Adult Onset, Lifestyle, Drugs, Research, Support
For more the more than 300,000 users that once relied on animal-derived insulin, the final chapter of animal insulin is finally ending for the US market. In December 2007, Novo Nordisk has officially decided to discontinue making animal-insulin. Their explanation doesn't go into great detail why they chose to discontinue it. But the supporting evidence they use to warrant the decision is a little weak.
Novo says, animal insulin is derived from the pancreas of slaughtered animals. This statement is as true as the statement "human insulin is derived from the pancreas of slaughtered humans". Novo continues, since that time there has been significant improvement of insulin quality and formulation. Absolutely true! In fact, a Novo pork product was shown to be greater than 99% pure, while an Eli Lilly human insulin only exceeded the 97 percentile. As a consequence, demand for these old animal insulins has declined by as much 20% in the last year to a point where approximately 2% of all insulin users are currently using these products. Largely due to the fact doctor's were advising their patients they must prepare to switch to GM insulin because animal-derived insulin would be nearly impossible to obtain. True. The research that introduced GM insulin (back in the 80s) was preemptive, at best. The claims supporting it was better than the existing insulin choices was clearly debatable .A telling similarity to the discovery about Avandia.
The long-term results of GM insulin and its analogs would prove to be a nightmare if the right questions were asked, and the data properly collected. Is it fair for any of the companies to ask us to change from an insulin product we have grown to love? No, but much like the off-Broadway play suggests: We love you (as a customer). Your diabetes is perfect (for our bottom line). Now change your insulin (we don't feel like making that kind anymore). Too bad type 1 diabetics forced to change to GM insulin didn't have the outspoken advocates like those taking Avandia.
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1. Lest we not forget that with rDNA(Human Insulin), it will be cheaper for Novo Nordisk and others to produce without being concerned about "limited supplies."
As we already know, not all insulins are the same. I do not mean in time of action and duration, but more importantly,in composition of elements contained within.
As soon as Human Insulin was substituted for Animal Derived Insulin, C-peptide was left out of the formulation.
It was felt by some of Researchers that C-peptide was nothing more than a step in the conversion of Pro-insulin to Insulin and had as its function only to show Insulin Availability throughout the body. So basically it was felt that it was almost vestigial as what the Tonsils and other Organs were once labeled until it was "discovered" that some of these so-called vestigial organs had benefits to the body that were not known before. In the case of the Tonsils, it was later discovered after many surgeries to "take out the tonsils,"that they were involved as a filter against disease organisms. They are still removed BUT ONLY if they become enlarged and infected, which was not the case before when they were frequently removed w/o infection.
So, using the same analogy, I am making in support of C-peptide. The Bibliography going back at least 20+ years shows that it has a beneficial effect in preventing and the possibe alleviation many Complications associated with Diabetes.
SoooooooooooooWHY REMOVE IT,or not make it available to those of us who wish to take it as part of "Good Diabetes Management?"
It can be developed as a separate vial similar to the way Symlin is.
TYPE 1 DIABETES IS MORE THAN ABOUT NUMBERS!! It has as part of its profile the onset of Complications which are related to Disease Longevity.
Posted at 12:32AM on May 25th 2007 by BetterCell