Who knew that all it took was removing the vagus nerve to prevent or reverse the development of insulin resistance. Wait -- what the hell is the vagus nerve? Turns out that it is a rather important nerve communicates with with just about everything in your body. It's truly no wonder that the terms 'vagus' itself is derived from the Latin word meaning "wanderer." And, thanks to researchers from Washington University School of Medicine in St. Louis, it has been found to play a very important role in preventing both diabetes and hypertension.
The scientists published their findings in the February issue of the journal Cell Metabolism, first pointing to a nuclear receptor they had previously highlighted called PPAR-Alpha (Ppara). This receptor had been shown to be necessary for the induction of both hypertension and diabetes when lab mice were treated with steroids. Considering that steroids are commonly prescribed for people who ave asthma, arthritis, and organ transplants, it has been suggested that this treatment has lead to insulin resistance and, in some cases, result in diabetes.
However, in the research team's most recent study, they found that both the Ppara and the vagus nerve play a significant role in the development of diabetes and hypertension. It appears as though by removing the vagus nerve, the risk of developing these disorders in response to steroid treatment, even if they have Ppara.
While the research on the interruption of nerve signals to the liver has only been performed on mice thus far, scientists are hopeful that their results will also hold true for humans.











1. Dr. Bernstein, in the his book 'The Diabetes Solution', emphasizes the importance of testing the vagus nerve in all his diabetic patients, T1s and T2s. Most diabetics have an impairment of the vagus nerve after having diabetes for several year. I have hhad D for 45 years. I had my vagus nerve checked and it is "dead", although my diabetes is very well controlled and a very healthy T1. My last HbA1c was 5.2%! I also have hypo unawareness. I am wondering if the hypo unawareness is perhaps related to the dysfunction of the vagus nerve? Also I find it interesting that I am not at all insulin resistant - my total daily dose of insulin is only 14U of humalog via an insulin pump! I find the research related to the role of the vagus nerve to diabetes (T1 and T2) very, very intriguing. All sorts of question arise!
Posted at 2:03AM on Feb 10th 2007 by Chrissie in Belgium