Lately a lot of attention has been focused on the Massachusetts General Hospital, one of the largest teaching hospitals of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of nearly $463 million. With deep pockets and medical moxie like that-would you expect the potential cure for type 1 diabetes to come from anywhere else?
In 1999, a MGH research study identified a gene malfunction that plays a pivotal role in the development of type 1 diabetes. The study showed that a gene required to help teach the immune system to recognize so-called "self" proteins is somehow inactivated, causing type 1 diabetes. Sounds like tricky stuff, but it prefaced a strong foundation for the prototype to cure type 1 diabetes. In 2001 MGH researchers found that by retraining the animal's immune system not to attack insulin-producing pancreatic beta cells, it would correct the autoimmune dysfunction causing type 1 diabetes. This research, in concert with a discovery made in 2003, whereby spleen cells appear to develop into insulin-producing cells, provided a revolutionary approach to curing type 1 diabetes. The National Institute of Health has recently confirmed this as a potential cure for type 1 diabetes.
Think of the illustrious contributions Harvard has bestowed on modern society in the form of witty-banter. The Harvard Lampoon, the Simpsons, and of course -- Conan O'Brien. It's only fitting that the cure for type 1 diabetes and other autoimmune diseases would come from the motherland of such mental marvels.











1. Lets hope you're right about MGH finding a cure, although we should contain our excitement at this point. The protocol has yet to be proven in human clinical trials, and as many rightly note, few of the many cures for NOD mice ever work in humans, so until the protocol is tested (scheduled for the future, I've read 2008 following completion of the blood assay later next year). Also, something else to note is the fact that the mice were treated with Freund's complete adjuvant. However, because its use in humans is forbidden (due to its toxicity), so the human clinical trials will test using a vaccine called Bacillus Calmette-Guerin (better known by its acronym BCG) instead. BCG is now known to induce the production of TNF in the body, which is hoped will destroy the abnormal T-cells which attack the insulin-producing beta cells in people type 1 diabetes.
Posted at 4:23PM on Dec 13th 2006 by Scott